Abstract
BackgroundLimited and inconsistent data are available regarding the relationship between the dietary inflammatory potential (DIP) and risk of gestational diabetes mellitus (GDM).ObjectiveThe present prospective study aimed to evaluate the association between DIP score during the first trimester of pregnancy and risk of developing GDM among Iranian women.MethodsIn this prospective cohort study, 812 pregnant women aged 20–40 years, who were in their first trimester, were recruited and followed up until week 24–28 of gestation. Dietary intakes of study subjects were examined using an interviewer-administered validated 117-item semi-quantitative food frequency questionnaire (FFQ). DIP score was calculated from 29 available food parameters based on earlier literature. The results of a fasting plasma glucose concentration and a 50-g, 1-h oral glucose tolerance test, between the 24th and 28th week of gestation, were used to diagnose GDM. The risk of developing GDM across quartiles of DIP score was estimated using Cox regression in several models.ResultsAt study baseline, mean (SD) age and BMI of study participants were 29.4 (±4.84) y and 25.14 (±4.08) kg/m2, respectively. No significant association was found between DIP score and risk of GDM in the crude model (RR: 1.01; 95% CIs: 0.71–1.45). When we adjusted for age the association did not alter (RR: 1.04; 95% CIs: 0.72–1.48). Even after further adjustment for maternal weight gain we failed to find a significant association between DIP score and risk of GDM (RR: 0.97; 95% CIs: 0.66–1.41).ConclusionWe found no significant association between DIP and risk of developing GDM. Further longitudinal studies among other populations are needed to elucidate the association between DIP score and GDM.
Highlights
Gestational diabetes mellitus (GDM) is a condition of glucose intolerance first diagnosed in the second or third trimester of pregnancy
We found no significant association between dietary inflammatory potential (DIP) and risk of developing gestational diabetes mellitus (GDM)
Further longitudinal studies among other populations are needed to elucidate the association between DIP score and GDM
Summary
Gestational diabetes mellitus (GDM) is a condition of glucose intolerance first diagnosed in the second or third trimester of pregnancy. A case-control study in Iranian women showed that a pro-inflammatory diet was associated with increased odds of GDM [35]. Studying the association between DIP score and GDM is relevant for Middle Eastern countries, where dietary intake and dietary inflammatory potential is very different from that found in other parts of the world. Given the limited and inconsistent findings about the association between the inflammatory potential of diet and risk of GDM, the aim of this study was to evaluate the association between DIP score during first trimester of pregnancy and risk of GDM among Iranian women. Limited and inconsistent data are available regarding the relationship between the dietary inflammatory potential (DIP) and risk of gestational diabetes mellitus (GDM)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
