Abstract
High titres of a cytopathic toxin were found in the faeces of four of six children with Hirschsprung's disease (congenital aganglionic megacolon). The toxin was fully neutralised by Clostridium sordellii antiserum. C. difficile was isolated from the faeces of five patients. In two of the four children from whom tissue specimens were obtained there were histological features of pseudomembranous colitis. C. difficile may be implicated in the pathogenesis of some cases of Hirschsprung's enterocolitis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
