Abstract
Background: Several studies had examined the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and methamphetamine (METH) use disorder, whereas the results were conflicting. The aim of this study was to conduct a meta-analysis to achieve a pooled effect size of the association between BDNF Val66Met polymorphism and METH use disorder.Methods: Literature searches were conducted in PubMed, EMBASE, and Cochrane Library up to July, 2020. All relevant studies on the relationship of BDNF Val66Met polymorphism and METH addiction were retrieved. Pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated in the dominant, recessive, co-dominant, and allele model to appraise the association.Results: Seven case–control studies with a total of 2,204 subjects (956 METH-dependent cases and 1,248 healthy controls) were included in this meta-analysis. The results showed a significant correlation between BDNF Val66Met polymorphism and METH dependence in overall population under different genetic models. However, subgroup analysis indicated that the association only existed in Han Chinese but not in other Asian populations.Conclusion: Although the current data indicate that BDNF Val66Met polymorphism might be a potential genetic factor for METH use disorder, more researches are needed to prove its role in different populations.
Highlights
Methamphetamine (METH) is highly abused throughout the world, which remains an extremely serious public health issue
All included studies met the following criteria: (a) studies focused on the association between Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and METH use disorder susceptibility, (b) patients were diagnosed using standard diagnostic criteria by a psychiatrist, (c) genotypes distribution of the control group should be in Hardy–Weinberg Equilibrium (HWE), and (d) there were sufficient data of the genotypes in the case and control group to compute the odds ratios (ORs) and 95% confidence intervals (CIs)
This study only focuses on the association between BDNF Val66Met polymorphism and METH-dependent susceptibility without considering gene–gene or gene–environment interactions. This conclusion still needs to be supported by more researches carried out in different populations, and more researches are needed to be conducted. This is the first meta-analysis to study the relationship between simple METH addiction and BDNF Val66Met polymorphism
Summary
Methamphetamine (METH) is highly abused throughout the world, which remains an extremely serious public health issue. Many genetic animal models supported the effects of genetic factors on METH addiction [6, 7]. Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family, which is widely expressed in the adult brain and plays a key role in the facilitation of development, differentiation, and survival of midbrain dopaminergic neurons as well as the modulation of synaptic transmission. Experiments on animal models showed that increasing BDNF expression could promote the survival and protection of dopaminergic neurons following METH administration [12, 13]. Several studies had examined the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and methamphetamine (METH) use disorder, whereas the results were conflicting. The aim of this study was to conduct a meta-analysis to achieve a pooled effect size of the association between BDNF Val66Met polymorphism and METH use disorder
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