Abstract
Background: Adiponectin is associated with improved systemic insulin sensitivity and profound positive effects in adipose tissue, such as increased mitochondrial density in adipocytes, reducing adipocyte size, and effective esterification of free fatty acids on lipid storage The factor performs forward transcriptional regulation. Diabetes and its complications are considered to be one of the main causes of morbidity and mortality worldwide. Aims and objectives: The aim of this study was to correlate serum levels of adiponectin with insulin resistance in Sudanese males' type 2 diabetes mellitus. Design and Methods: A case-control community-based study carried out among 126 patients with T2DM as cases group (mean ages 45.2±5.4 years); and 126 normal healthy individuals as controls group (mean ages 44.7±5.4 years as) in Aldaraga Diabetic Center, Wad Medani, Gezira State, Sudan. About Five mL of fasting venous blood was obtained from all participants. HbA1c, FPG, FPI, serum Adiponectin, and (HOMA)- IR were analyzed. SPSS (v 20.0) was used for data analysis. Results: The mean of serum adiponectin in the cases group (3.03±0.90µg/ml) was lower than the control group (6.02±4.24µg/ml) giving highly significant differences -between them (P=value ≤ 0.000). HbA1c and Homeostasis Model Assessment of Insulin Resistance index (HOMA-IR) differed significantly between the two groups (P-value ≤ 0.000). Serum adiponectin concentrations correlated significantly negative with HOMA IR (r = -0.149, P-value = 0.002). Conclusion: We concluded that low plasma adiponectin level was predictive of future development of Insulin resistance in Sudanese males.
Highlights
Adipose tissue dose not store fat, energy storage, and insulation but is an important endocrine organ that secretes bioactive proteins, into the circulation, such as tumor necrosis factor (TNFα) and adiponectin (1), it can be secreted by epicardial fat, hepatocytes and skeletal muscle (2)
Serum adiponectin concentrations correlated significantly negative with HOMA IR (r = -0.149, P-value = 0.002)
We concluded that low plasma adiponectin level was predictive of future development of Insulin resistance in Sudanese males
Summary
Adiponectin is associated with improved systemic insulin sensitivity and profound positive effects in adipose tissue, such as increasing mitochondrial density in adipocytes, reducing adipocyte size, and effective esterification of free fatty acids on lipid storage The factor performs forward transcriptional regulation. Diabetes and its complications are considered to be one of the main causes of morbidity and mortality worldwide
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