Abstract
Background: Identification of novel genetic factors for Depressive Disorders (DD) represents a major challenge around the world. Molecular studies of endophenotypes associated with DD, such as personality traits and coping, are powerful strategies for finding genetic markers. Objective: The main objective of this work was to confirm the potential relationship between a functional polymorphism in the monoamine oxidase A (MAOA) gene and scores in coping and neuroticism in young adults. Methods: A Colombian sample of two hundred fifty-one young participants was evaluated with the short forms of the Coping Inventory for Stressful Situations (CISS-SF) and the Big Five Inventory (BFI-S). Genotypes for MAOA-VNTR polymorphism were obtained by PCR. Results: A significant relationship between the functional MAOA-VNTR polymorphism and scores in both emotion-oriented coping and neuroticism was found. Individuals carrying the 4 allele (3/4 or 4/4 genotypes) had higher scores for both emotion-oriented coping and neuroticism than individuals with a 3/3 genotype. Conclusion: Our current findings are novel in terms of being the first report of a relationship between a functional polymorphism in the MAOA gene and coping and add evidence to the association of this gene with neuroticism. Our results expand the associations between MAOA gene and multiple dimensions of human emotion and personality.
Highlights
The identification of genetic risk factors for Depressive Disorders (DD) represents a major challenge around the world [1 - 3]
Our current findings are novel in terms of being the first report of a relationship between a functional polymorphism in the monoamine oxidase A (MAOA) gene and coping and add evidence to the association of this gene with neuroticism
Our results expand the associations between MAOA gene and multiple dimensions of human emotion and personality
Summary
The identification of genetic risk factors for Depressive Disorders (DD) represents a major challenge around the world [1 - 3]. There is the need for more studies to find the molecular risk factors and pathophysiological mechanisms underlying DD [3, 4]. Genetic studies of the endophenotypes associated with DD, such as personality traits and coping, are useful for the identification of candidate genes [1]. Personality traits have been studied extensively for decades, using approaches from psychology, neurosciences and genetics [5, 6]. Identification of novel genetic factors for Depressive Disorders (DD) represents a major challenge around the world. Molecular studies of endophenotypes associated with DD, such as personality traits and coping, are powerful strategies for finding genetic markers
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