Association between 25-hydroxyvitamin D3 and metabolic syndrome in middle-aged and elderly population

Abstract

Objective To evaluate the association between 25-hydroxyvitamin D3 [25 (OH) D3] and metabolic syndrome(MS) as well as the components of MS in middle-aged and elderly population.Methods A total of 463 individuals (190 male cases and 273 female cases) aged 50-70 years with more than 10 years of residence in Zhaiji community of Guiyang city were recruited by cluster random sampling method.A standard questionnaires,anthropometric parameters,blood lipids,blood glucose,fasting insulin,plasma 25 (OH)D3 concentration were tested.MS was diagnosed according to the International Diabetes Federation (IDF) criteria.Results (1) The mean25(OH)D3 concentration was (21.98±8.32) ng/ml.Prevalence of MS was 38.9 ％.In 25 (OH) D3 deficiency,insufficiency,and sufficiency group,the prevalence of MS were 82.8％,and 26.6％ (P ＜ 0.05).(2) Compared with 25 (OH) D3 abnormal group,the male percentage,education and calcium supplement in 25 (OH) D3 sufficiency group were higher(P ＜ 0.05) and waist circumference,fasting plasma glucose,oral glucose tolerance test 2 hours glucose,triglyceride,homeostasis model of assessment for insulin resistance index (HOMA-IR)was lower (P ＜0.05).(3)An inverse associations existed between 25 (OH) D3 levels and MS prevalence [β =-0.667,odd ratio (OR) =0.513,P ＜ 0.05].Plasma 25 (OH)D3 concentration was significantly and negatively associatied with waist circumference,fasting plasma glucose,triglyceride and HOMA-IR (P ＜ 0.05).Conclusions Middle-aged and elderly people with lower 25 (OH)D3 level has higher MS prevalence.A low 25 (OH)D3 level may increase the risk of MS and components of MS. Key words: 25-Hydroxyvitamin D3 ; Metabolic syndrome; Middle-aged and elderly people