Abstract
Background: Pregnancy continues to be an event full of risks, complications and adverse outcomes for women despite advanced clinical and diagnostic methods and treatment options available in medicine. Diabetes, as a multifactorial and complex disease, is a possible outcome of a blend of numerous genetic variants of differing scarcities. The exact etiology of gestational diabetes mellitus (GDM) is unclear; however, the interaction of genetic and environmental factors, especially the genetic variants identified as the genetic loci for type 2 diabetes as candidate genes for GDM.
 Methodology: It will be a case-control study with a genetic analysis of single nucleotide polymorphisms (SNPs) of candidate genes expressed using real-time PCR with sequencing. The study will also evaluate the primer sequence of SNPs.
 Discussion: We will be able to share the findings after the completion of our research. The results of this study will able helpful in addressing the psycho-physiological needs of women with GDM, which may also be used to devise strategies to benefit the sustainable long-term behavioural change following the affected pregnancy.
Highlights
Pregnancy continues to be an event full of risks, complications and adverse outcomes for women despite advanced clinical and diagnostic methods and treatment options available in medicine
The current study aims to describe and quantify the association of candidate genes (OXTR & melatonin receptor type 1B (MTNR1B)) single nucleotide polymorphisms (SNPs) with psychological symptomatology in women with gestational diabetes mellitus (GDM)
; GDM is a transient disorder in the majority of pregnancies but, it is inclined to be superimposed by stress, which has long-lasting adverse effects on maternal and child health[20]
Summary
Pregnancy continues to be an event full of risks, complications and adverse outcomes for women despite advanced clinical and diagnostic methods and treatment options available in medicine One such complication is an alteration of glucose metabolism due to insulin resistance under the influence of placental hormones. The exact etiology of GDM is unclear; several recent studies have highlighted the interaction of environmental and genetic factors, especially the genetic variants identified as the genetic loci for type 2 diabetes as candidate genes for GDM. The exact etiology of gestational diabetes mellitus (GDM) is unclear; the interaction of genetic and environmental factors, especially the genetic variants identified as the genetic loci for type 2 diabetes as candidate genes for GDM. The results of this study will able helpful in addressing the psycho-physiological needs of women with GDM, which may be used to devise strategies to benefit the sustainable long-term behavioural change following the affected pregnancy
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