Association analysis of physical activity levels with mental state and quality of life in Chinese patients with inflammatory bowel disease: A multicenter study.

The primary objective was to compare health outcomes (balance, functional capacity, lower extremity strength, fear of falling, sleep quality, and quality of life) between older adults with higher and lower levels of physical activity. A secondary objective was to explore whether these health-related factors mediated the association between physical activity level and quality of life. A comparative cross-sectional study involved 88 older adults with higher levels of physical activity (higher-PA group) and 88 with lower levels of physical activity (lower-PA group), who underwent mobility tests including the Timed Up and Go Test (TUGT), 2-Minute Walk Test (2MWT), and 10-Meter Walk Test (10MWT); balance and strength assessments such as the Modified Clinical Test of Sensory Interaction in Balance (mCTSIB) and Five-Time Sit-to-Stand Test (5xSTST); and completed self-reported questionnaires including the Fall Efficacy Scale-International (FES-I), Pittsburgh Sleep Quality Index (PSQI), and World Health Organization Quality of Life - Brief (WHOQOL-BREF) Primary analyses compared outcomes between groups with lower and higher levels of physical activity. Mediation analysis was performed to explore indirect effects of balance, fear of falling, lower extremity strength, and sleep quality on the relationship between PA level and Quality of Life (QoL). A total of 176 participants with a mean ± SD age of 65.90 ± 3.84 years and a mean BMI of 23.08 ± 1.43 kg/m² were included. Higher-PA group demonstrated significantly better performance on TUGT, 2MWT, and 10MWT than the lower-PA group, with the younger higher-PA group showing greater 2MWT scores. They demonstrated significantly better mCTSIB, FES-I, and PSQI scores than the lower-PA group. Participants with higher levels of physical activity showed significantly lower FES-I and 10MWT scores compared to those with lower levels. Additionally, mCTSIB scores were significantly influenced by age, income, and occupation, with higher physical activity levels associated with higher mCTSIB scores. Higher-PA group reported significantly better physical and psychological health and environmental and social relationships in QoL domains. Furthermore, adequate sleep duration was significantly associated with improved sleep quality. Parallel mediation analyses revealed that in the physical health domain, all mediators showed significant partial mediation, with the strongest indirect effect via 10MWT (β = 1.116, p = .003). In the psychological domain, PSQI emerged as the most prominent mediator (β = 1.061, p = .001). For the social relationship domain, 2MWT demonstrated the strongest mediation effect (β = 0.546, p = .006). In the environmental health domain, only PSQI (β = 0.475, p = .002) and FES-I (β = 0.239, p = .047) showed significant partial mediation. While controlling for sociodemographic characteristics in the models, all domains showed significant total effects, with partial mediation observed through psychosocial and physical performance variables; however, none of the indirect effects reached statistical significance. Older adults engaging in higher levels of physical activity demonstrated markedly better mobility, balance, and overall QoL compared to their less active counterpart. Physical activity positively influenced all domains of QoL through multiple functional pathways, with significant partial mediation observed via mobility, balance, sleep quality, and fear of falling, most notably within the physical and psychological domains. However, after adjusting for key sociodemographic covariates, the indirect effects were no longer statistically significant. These results highlight the critical role of functional capacities in translating physical activity into improved well-being among older adults.

Background Existing evidence suggests that physical activity, in addition to medical treatment, can counteract physical symptoms and improve the quality of life in patients with inflammatory bowel disease (IBD). We aimed to understand patients' patterns of physical activity to guide the development of an evidence-based personalised intervention for the promotion of physical activity and reduction of sedentary behaviour in patients with IBD. Methods We included a population of 207,959 participants who responded to The Danish Capital Region Health Surveys during the period 2007 to 2021. The population included 1777 individuals with prevalent IBD [705 with Crohn’s disease and 1072 with ulcerative colitis]. Information on sedentary behaviour and physical activity was obtained from self-reported questionnaires, the Physical Activity Scale version 2.1., and sociodemographic information from central nationwide registers. Self-rated physical and mental health was measured with SF-12. Data were weighted for survey design and were analysed by multiple regression analyses. Results The proportion that adopted the recommended physical activity level of at least 4 hours of low, moderate, or high intensity was lower among patients with IBD compared to the background population, also when adjusting for sociodemographic variables and population weights (OR=0.86; 95% CI 0.84-0.88). Among patients with IBD, more women than men were physically active. Crohn’s disease, living alone, having non-western ethnicity, having a BMI< 18.5 or BMI >30, having an unhealthy diet, being outside the labour market, and having small children were all associated with lower levels of physical activity. Moderate to high level of physical activity among patients with IBD was associated with higher self-rated physical health than low levels of physical activity (p<0.001). The highest mental quality of life score was among IBD patients with moderate physical activity compared to high or low physical activity (p<0.001). Conclusion Patients with IBD, especially those with Crohn’s disease, have lower levels of physical activity and more sedentary behaviour compared to non-IBD individuals. Moderate physical activity is associated with a higher physical and mental quality of life score in individuals with IBD compared to high or low levels of physical activity. These results can guide clinicians when IBD patients ask for advice on physical activity. Furthermore, we will use the results to guide the development of an evidence-based personalised intervention for the promotion of physical activity and reduction of sedentary behaviour in patients with IBD.

To investigate the association between diabetes symptoms and physical activity (PA) levels among middle-aged and older Chinese adults. Data for this study were obtained from 2018 Charles data. Z test, logistic regression analysis, and linear hierarchical regression analysis were performed in 5352 individuals aged ≥50 years with complete information. In terms of diabetes, 6.8% of the middle-aged and elderly people with diabetes were detected, and 93.2% of the middle-aged and elderly people without diabetes symptoms. The proportion of middle-aged and elderly people with high PA levels was 50.5%, and the proportion of middle-aged and elderly people with low PA was 49.5%. There was a significant positive correlation between low PA and diabetes (P < .05). After adjusting demographic characteristics (gender, registered permanent residence type, education level, age, widowhood) and health status characteristics (poor mood, asthma, hyperlipidemia, disability, memory disease, self-assessment of health status, hypertension, smoking, stroke, depression), there was still a statistical significance between PA level and diabetes (P < .05). The risk of diabetes of middle-aged and elderly people in China increases with age, while the risk of diabetes of middle-aged and elderly people with low level of PA is higher. The risk of diabetes is high among middle-aged and elderly people who are old, have poor self-evaluation health, suffer from hyperlipidemia, memory disease, and asthma. The middle-aged and old people should increase their PA levels to prevent and improve diabetes.

Objectives: The mechanisms by which overweight and physical inactivity lead to hypertension are complex. Leptin, an adipocyte-derived hormone, has been linked with hypertension. We studied the relationship between leptin, physical activity, and new-onset hypertension. Methods: A prospective study design based on data from the 3. and 4. Copenhagen City Heart Study (CCHS). From the 3. CCHS, which was performed in 1991 to 1994, we identified 1111 subjects (744 women and 367) who were normotensive. Based on questionnaire items, the participants were divided into two groups with low (n = 674) and high (n = 437) level of leisure time physical activity, respectively. Between the 3. and the 4. CCHS examination, which was performed in 2001 to 2003, 304 had developed hypertension, defined as systolic blood pressure (SBP) ≥140 mm Hg or diastolic blood pressure (DBP) ≥90 mm Hg or use of antihypertensive medication. Results: In a logistic regression model, including age, sex, body mass index, SBP, DBP, level of physical activity, and leptin, we found a significant interaction between leptin and level of physical activity with new-onset hypertension as outcome variable (P = 0.012). When we entered the interaction variables: effect of leptin with low level of physical activity and with high level of physical activity, respectively, in the original model, leptin only predicted new-onset hypertension in participants with low level of physical activity (odds ratio (95% confidence interval): 1.16 (1.01–1.33) for one unit increase in log-transformed leptin levels, P = 0.038), but not in participants with high level of physical activity (0.88 (0.74–1.05), P = 0.15). If we included other risk factors of hypertension and possible mediators of overweight-related hypertension, such as the triglyceride to HDL cholesterol concentration ratio, fibrinogen, glucose, diagnosis of diabetes, adiponectin, and heart rate, in the model, leptin still predicted new-onset hypertension in participants with a low level of leisure time physical activity (P = 0.040). Conclusion: This study is the first prospective study to report that the hypertensive effect of leptin is modified by leisure time physical activity.

Study purpose. The objective of the study was to assess the relationship between quality of life and physical activity level and family well-being.&#x0D; Materials and Methods. The International Physical Activity Questionnaire (IPAQ) was used to assess parental physical activity. The quality of life was assessed with the Short Form (SF-36) Health Survey Questionnaire. The data obtained were processed using cluster and correlation analysis, and descriptive statistics. The study involved 106 young adults (married couples), who were parents of preschool and primary school-aged children.&#x0D; Results. An assessment of parental physical activity showed that 62.3% of the respondents had a low level of physical activity and 37.7% had a moderate level, whereas no individuals with a high level of physical activity were found. Families with children were divided into clusters with the k-means method according to the level of physical activity: Cluster 1 included families with a low level of physical activity; and Cluster 2 included the families with a moderate level of physical activity. The results of the study confirmed the relationship between the quality of life and the level of physical activity and family well-being. It was found that all the quality of life components of the study participants with a moderate level of physical activity are significantly higher (р&lt;0.05) than those of the participants with a low level of physical activity. Correlation analysis of family well-being and quality of life indicators revealed significant relationships (p&lt;0.05) between physical functioning, physical role functioning, vitality, and mental health.&#x0D; Conclusions. The direct statistically significant relationship between family well-being score and quality of life components of the respondents was demonstrated.

Objective. The mechanisms by which overweight and physical inactivity lead to hypertension are complex. Leptin, an adipocyte-derived hormone, has been linked with hypertension. We wanted to investigate the relationship between leptin, physical activity and new-onset hypertension. Methods. The study was a prospective cohort study of 744 women and 367 men, who were normotensive in the third Copenhagen City Heart Study (CCHS) examination, performed 1991–94. Based on questionnaire items, the participants were divided into two groups with low (n = 674) and high (n = 437) levels of leisure-time physical activity, respectively. Results. Between the third and the fourth CCHS examination, performed 2001–03, 304 had developed hypertension, defined as systolic blood pressure (SBP) ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg or use of antihypertensive medication. In a logistic regression model, including age, sex, body mass index, SBP, DBP, level of physical activity and leptin, we found a significant interaction between leptin and level of physical activity with new-onset hypertension as outcome variable (p = 0.012). When we entered the interaction variables, effect of leptin with low level of physical activity and with high level of physical activity, respectively, in the original model, leptin predicted new-onset hypertension in participants with low level of physical activity [odds ratio (95% confidence interval): 1.16 (1.01–1.33) for one unit increase in log-transformed leptin levels, p = 0.038], but not in participants with high level of physical activity [0.88 (0.74–1.05), p = 0.15]. Conclusion. We found that leptin predicted new-onset hypertension but only in participants with low level of physical activity.

Background and Objectives: Menopause is a normal physiological change occurring at a woman’s mid-life. During this time, women experience vasomotor, physical and physiological problems, which reduce their quality of life. Many women are searching for different, alternative methods to reduce the severity of menopausal symptoms. Physical activity (PA) is one of the recommended methods to reduce menopausal symptoms. The purpose of this study was to investigate the association between specific domains (physical activity during leisure time, at work, during transportation and household activities) and the menopausal symptoms. Materials and Methods: We included 305 women aged 40–65 in the study. All participants were divided into three groups according to menopausal status. The research tools used were the International Physical Activity Questionnaire (IPAQ) to assess physical activity level in four domains and the Menopause Rating Scale (MRS) to assess the severity of menopausal symptoms. The data analysis was performed by Chi-square test and analysis of variance (ANOVA) with post hoc Tuckey test. Results: Menopausal stage was significantly associated with the total MRS score (p < 0.001) and specifically the urogenital and somato–vegetative subscores (p < 0.001). Physical activity was significantly associated (p < 0.001) with leisure time (according to IPAQ domains). Most postmenopausal women had high PA level (59.66%). Significantly less women with high PA levels had severe urogenital symptoms: 10.82% of participant with a low PA level, 11.15% with a moderate PA level and 4.26% with a high PA level (p = 0.046). Conclusions: Physical activity during leisure time is associated to menopausal symptoms in Polish women. Women with high and moderate PA levels have less severe menopausal symptoms compared to inactive women. Middle-aged women with low PA levels at work suffer from more severe somato–vegetative symptoms.

Occupations might influence the employees' psychophysical conditions and an important issue is the human activity mechanization, which favors a hypokinetic work status and leads to several chronic diseases. One of the most hypokinetic occupations is the supermarket cashier, in which the individual may spend many hours a day in the same body position. The goal of this study was to evaluate the association between cardiovascular risk, quality of life and physical activity level in supermarket cashiers. This is a cross-sectional study which included 200 supermarket cashiers aged 20 to 41 years from São Paulo, Brazil. The following cardiovascular risk factors were evaluated: overweight, obesity, hypertension, diabetes mellitus, and tobacco smoking. Physical activity level and quality of life were assessed with the short-form of the International Physical Activity Questionnaire (IPAq) and World Health Organization Quality of Life (WHOQOL), respectively. Student t test and Chi-square were carried out to evaluate mean gender comparations and frequency, respectively. Logistic regression models were applied to determine the association between cardiovascular risk factors and physical activity level. The prevalence for all cardiovascular risk factors was significantly high in the cashiers with a low physical activity level. However, there was a significant reduction in several risk factors in the groups with moderate and high physical activity levels. The odds ratio values were significantly reduced for the association between the cardiovascular risk factors and the moderate and high physical activity levels. The cashiers with moderate and high physical activity levels showed significantly higher quality of life scores for the social and environmental domain. A high physical activity level is positively related to quality of life in supermarket cashiers.

FRI0634-HPR LEVEL OF PHYSICAL ACTIVITY IN ANTIPHOSPHOLIPID SYNDROME AND ITS RELATIONSHIP TO ATHEROSCLEROSIS PROGRESSION – ANALYSIS OF THE SERBIAN COHORT

Objective: To explore the relationship between physical activity level and quality of life among people aged 50 years and over. Methods: From October 2009 to June 2010, 8 872 middle-aged and elderly people aged 50 years and over, were selected from five districts of Shanghai, by multi-stage random cluster sampling method. Both Global Physical Activity Questionnaireand World Health Organization Quality of Life Scale (WHOQoL-8) were used to assess the physical activity, level and quality of life. A two-level (individual level and community level) linear model was used to analyze the relationship between physical activity level and quality of life in different age groups. Results: A total of 8 454 individuals aged (63.16±9.74) years were included in this study. 59.95% of the people in this study were with low physical activity level, while 28.00% and 12.05% of them were with medium or high levels of physical activities. The WHOQoL-8 score appeared as 43.91±0.69. The higher the level of physical activity, the lower the WHOQoL-8 score was, referring to a better quality of life (P=0.00). After controlling the confounding factors of socio-economic factors, health status and social participation, the increase of physical activity level showed significant effect in improving the quality of life for the middle-aged and under 80 elderly (P<0.05). However, compared with the low-level, middle and high-level physical activities did not improve the quality of life among the people aged 80 years and over. The P values were 0.06 and 0.47, respectively. Conclusion: Higher level of physical activity appeared its relations to a better quality of life among people aged between 50 and 80, in Shanghai.

BackgroundParticipating in physical activity after a diagnosis of cancer is associated with reduced morbidity and improved outcomes. However, declines in, and low levels of, physical activity are well documented in...

Physical activity in the prevention and treatment of obesity and its comorbidities: evidence report of independent panel to assess the role of physical activity in the treatment of obesity and its comorbidities.

The nature of changes in the immune system during physical work is a complex process involving many different mechanisms. Research in this direction is an urgent problem. The purpose of the research was to study the indicators of cellular and humoral immunity in students with different levels of physical activity. A total of 77 male students were examined, consisting of 3 groups: 1) with a low level of physical activity (n = 32) – students who were not involved in sports activities on a regular basis; 2) students with an average level of physical activity (n = 22) – beginner sambo wrestlers without sports categories; and 3) students with a high level of physical activity (n = 23) – highly qualified sambo wrestlers – first-class athletes, candidates for masters and masters of sports. In students of all groups, the quantitative content of various phenotypes of lymphocytes in the blood was studied by flow cytometry; serum immunoglobulin levels by laser nephelometry; phagocytic parameters by traditional methods; and oxygen-dependent metabolism of neutrophils by chemiluminescence. In students with a high level of physical activity, the content of T and B lymphocytes in the blood was significantly increased compared to similar indicators of the group with a low level of physical activity and the group of students who did not participate in sports. The concentration of class G immunoglobulin in the blood serum of students with a high level of physical activity significantly exceeded the corresponding values in students with an average level and students not engaged in sports. The highest concentration of class M immunoglobulin was observed in students with high levels of physical activity. Phagocytic activity and phagocytic count in individuals with high levels of physical activity and neutrophils were significantly higher than those of students with medium and low levels of physical activity. The rates of spontaneous and induced chemiluminescence in the groups with high and medium levels of physical activity were significantly higher than in students with low levels. The studies carried out indicate the positive effect of regular training physical activity on the factors of humoral and cellular links of immunity in students in the conditions of the educational environment of a higher educational institution.

Physical activity for people living with the human immunodeficiency virus

The transition from general education school to university is a critical period for young adults. University freshman are exposed to a variety of new experiences and potential lifestyle changes that may influence their health and risk of obesity, including changes in eating habits and daily physical activity. Physical activity and nutrition are important factors affecting the health of students. The aim of the study was to identify the relation between eating habits and physical activity level among the students of Lithuanian University of Educational Sciences. The methods of research: scientific literature analysis, self-report questionnaire. The anonymous questionnaire used in the survey was made according to FINBALT HEALTH MONITOR standardized questionnaire and International Physical Activity Questionnaire – Short Form (IPAQ-SF). The survey was conducted in 2013–2014. The sample consisted of 432 first year students (141 men and 291 women) of Lithuanian University of Educational Sciences. Statistical analysis: the data were analyzed using SPSS software package, version 16.0. Chi-square statistics was used to examine differences in frequencies of responses to questions on eating habits and physical activity (PA) levels. Differences were considered statistically significant at p < 0.05. The research data shows that similar percentage of students (72.9 % as having low level PA, 75.2 % – as moderate level PA, 62.2 % – as high level PA) typically eat three or four times a day. Also, 61.3 % of them have breakfast, and 79.9 % have lunch every day. The daily recommended amount of water is drunk by 42.6 % of the respondents: 24.3 % as having low level PA, 38 % – as moderate level PA, 50.6 % – as high level PA (χ² = 19,777, p < 0.01). Also, not even a single time during the week, 56.2 % of the students ate fish, 31.7 % cheese, 30.7 % drank milk and 40.3 % yogurt. Students with high level PA more often ate rice (p < 0.01) and white cheese (p < 0.05). The findings of the present study showed that some students’ diet is not favorable to their health – they often do not respect the dietary regimen, too rarely use indispensable foods. Results revealed that students who engaged in low levels, moderate levels and high levels of physical activity had similar eating habits. Keywords: physical activity level, eating habits, university students. DOI: http://dx.doi.org/10.15823/sm.2015.17