Assisted reproductive technology in Beijing, 2013-2015.

Abstract

Why are comprehensive and detailed reports of local or national utilization outcomes of assisted reproductive technology (ART) lacking in China? Retrospective collection of data on intrauterine insemination (IUI) and IVF and intracytoplasmic sperm injection (ICSI) in Beijing, including all 12 registered institutions with cycles, started between 1 January 2013 and 31December 2015. Clinical pregnancy rates (CPR) per aspiration and fresh embryo transfer were 39.1% and 43.2% in 2013, 40.1% and 45.4% in 2014, and 37.8% and 44.5% in 2015; live birth rates (LBR) per aspiration and per fresh embryo transfer were 31.7% and 35.0%, 32.3% and 36.6%, and 30.3% and 35.6%, respectively. In frozen embryo transfer (FET) cycles, the CPR per thawed transfer was 43.4%, 47.2% and 46.2%, respectively, resulting in LBR of 34.3%, 37.4% and 36.5%. The prevalence of multiple pregnancies was 28.0-31.3% for fresh embryo transfer, and 23.5-25.9% for FET. The LBR was 8.8-9.1% after IUI with husband or partner's semen (IUI-H), and 16.7-19.7% after IUI with donor semen (IUI-D). The birth defect rate among live born infants was 1.52%, 0.42% and 0% after IUI-H, 1.05%, 0.39% and 0.66% after IUI-D, 0.71%, 0.56% and 0.46% after fresh embryo transfer, and 0.73%, 0.20% and 0.18% after FET in 2013, 2014 and 2015, respectively. In Beijing over 3 years, the number of IVF-ICSI cycles has increased and the number of IUI cycles has decreased; IVF-ICSI outcomes are better and safer. Further effort should be made to lower the multiple pregnancy rates. A Chinese nationwide ART registry should be promoted.