Abstract
Oral contraceptives have been useful in birth control and other gynecological disorders; it is sometimes abused due to ignorance and other underlying factors. The liver is saddled with the responsibility of drug metabolism. This study assessed the effect of oral contraceptives on the liver functionality and integrity. A total of 25 female albino rats were obtained and allowed to acclimatize in the animal house of the department of Pharmacology, Rivers State University for 7 days. The rats were divided into five groups of five animals in each group. Group 1 served as control, Group 2 and 3 were administered with low and high doses of Exluton, while group 4 and 5 were administered low and high doses of Combination-3 respectively. The albino rats in all groups were allowed feed and water ad libitum. The experimental process lasted for 21 days, after which the animals were sacrificed, blood samples collected into sterile bottles for biochemical assay using standard laboratory procedures, while the liver was harvest for histological examination. The results obtained from analysis revealed a slight insignificant increase in the concentration of serum AST when administered Exluton and Combination-3 at both doses. ALP serum concentration reduced at all doses of the drugs administered, while ALT had an inconsistent variation. Total protein and ALB decreased in concentration while Bilirubin had an increased serum concentration. This study suggests impairment on the functionality and the integrity of the liver on administration of Oral contraceptives over a long period, dose dependent and a possible distortion in platelet function. The biliary system of the liver however may not be altered.
Highlights
Combined oral contraceptive pills are a type of oral medication that is designed to be taken every day, at the same time of day, in order to prevent pregnancy [1]
AST: Aspartate-amino transferase, ALT: Alanine-amino transferase, ALP: Alkaline phosphatase; Values are Mean± Standard deviation and values within each liver and biliary integrity parameters having different superscript are statistically significant at p
TP: Total protein; ALB: Albumin; TB; Total bilirubin; CB: Conjugated bilirubin; Values are Mean± Standard deviation and values within each liver and biliary integrity parameters having different superscript are statistically significant at p
Summary
Combined oral contraceptive pills are a type of oral medication that is designed to be taken every day, at the same time of day, in order to prevent pregnancy [1]. If used exactly as instructed, the estimated risk of getting pregnant is 0.3%, or about 3 in 1000 women on combined oral contraceptive pills (COCPs) will become pregnant within one year [2]. The estimated risk of getting pregnant is about 9%, or about 9 in 100 women on COCP will become pregnant in one year [3]. Exluton is a brand of progesterone only pill containing 500mirogram of lynestenol in each tablet. It is mainly used when COCPs are contraindicated like during breast feeding and serves to prevent pregnancy
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: World Journal of Biology Pharmacy and Health Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
