Abstract
BackgroundThrombocytopenia is commonly observed among critically ill patients.AimThe aim of this study was to evaluate the incidence, risk factors, and the outcome of thrombocytopenia in patients admitted to the respiratory intensive care unit (RICU).Materials and methodsData were collected from 50 adult patients admitted to the RICU in a 6-month period. The baseline platelet count was measured and was repeated every other day during the RICU stay period. Thrombocytopenia was defined as platelet count of less than 150´109/l.ResultsThe incidence of thrombocytopenia was 20% (10 patients). The overall mortality was 16%, of which 50% of the patients were having thrombocytopenia. The thrombocytopenic group had a higher mortality (40 vs. 10%, P < 0.05), a lower admission platelet count (215.3 ± 85.6 vs. 252.8 ± 73.2, P < 0.05), a lower nadir platelet count (111.1 ± 22.6 vs. 213.9 ± 53.2, P < 0.001), an increased transfusion requirement (30 vs. 2.5%, P < 0.05), and increased septic shock (40 vs. 2.5%, P < 0.05) compared with the nonthrombocytopenic group. Comorbidities, indications for RICU admission, the length of RICU stay, mechanical ventilation, days on mechanical ventilation, admission severity scores, bleeding, ICU-related complications, and medications administrated during the RICU stay did not differ significantly. A prolonged RICU stay of more than 15 days carried a 4.7 times higher incidence of development of thrombocytopenia. Thrombocytopenia differed significantly between survivors and nonsurvivors (P < 0.05), with a significant effect on mortality (P = 0.034).ConclusionThrombocytopenia is common among critically ill patients and affects the mortality significantly. Prolonged ICU stay and septic shock are among the risk factors for thrombocytopenia. Egypt J Broncho 8:143–148
Highlights
Thrombocytopenia is defined as a platelet count of less than 150 × 109/l [1,2,3,4,5]
The thrombocytopenic group had a higher mortality (40 vs. 10%, P < 0.05), a lower admission platelet count (215.3 ± 85.6 vs. 252.8 ± 73.2, P < 0.05), a lower nadir platelet count (111.1 ± 22.6 vs. 213.9 ± 53.2, P < 0.001), an increased transfusion requirement (30 vs. 2.5%, P < 0.05), and increased septic shock (40 vs. 2.5%, P < 0.05) compared with the nonthrombocytopenic group
Comorbidities, indications for respiratory intensive care unit (RICU) admission, the length of RICU stay, mechanical ventilation, days on mechanical ventilation, admission severity scores, bleeding, ICU-related complications, and medications administrated during the RICU stay did not differ significantly
Summary
Thrombocytopenia is defined as a platelet count of less than 150 × 109/l [1,2,3,4,5]. The various comorbidities in the severely ill patient affect platelet homeostasis, and thrombocytopenia is very common in critically ill patients treated in the ICU. Thrombocytopenia in critically ill patients is associated with an increased duration of hospital stay and increased mortality [3,4,6,7,8,9]. This study aimed at evaluating the incidence, risk factors, and the outcome of thrombocytopenia in patients admitted to the respiratory intensive care unit (RICU). Thrombocytopenia is commonly observed among critically ill patients
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