Abstract
Background: Cystic echinococcosis (CE) is a highly prevalent parasitic disease resulting from the hydatid cyst of Echinococcus granulosus. It is also described as a zoonotic disease and considered a neglected tropical infection. Aim: This study assessed the antiparasitic activity of silver nanoparticles (AgNPs), against E. granulosus infection in BALB/c mice. Methods: The green synthesis of AgNPs was accomplished using Zizyphus spina-christi leaves. AgNPs were orally administered to BALB/c mice for acute short-term toxicity evaluation, in doses of 50 mg, 100 mg, 200 mg, and 300 mg/kg, and observations for toxic signs were carried out at 24, 48 h, and 14 days, continuously. Moreover, a total of 20 mice divided into two groups were intraperitoneally administered with 1500 viable protoscoleces for secondary hydatidosis infection. Results: The results showed that AgNPs did not induce any adverse effects or signs and no death, in either group of mice. The histopathological findings in the liver, kidneys, and intestine of the mice administered with AgNPs revealed mild histological effects compared with the control ones. The treated-infected mice showed a change in the appearance of the liver hydatid cysts from hyaline to milky cloudy compared with the untreated infected mice. Conclusion: Biosynthesized AgNPs showed anti-hydatic effects and are suggested as anti-echinococcal cyst treatment.
Highlights
Cystic echinococcosis (CE) is a widely distributed parasitic disease resulting from the hydatid cyst caused by E. granulosus
This study aimed to investigate the effect of the green AgNPs against secondary hydatid cysts within experimentally infected mice
The peaks are associated with π to π* transition, which is related to the phytochemical constituents of the leaf extract. They can be considered as a source for the green synthesis of metallic and metal oxide nanoparticles
Summary
Cystic echinococcosis (CE) is a widely distributed parasitic disease resulting from the hydatid cyst caused by E. granulosus. It is described as a zoonotic disease and referred to as hydatid disease or hydatidosis [1]. It is one of the country’s most significant helminthic infections with significant socioeconomic impacts due to the effect on both humans and their livestock [3]. Cystic echinococcosis (CE) is a highly prevalent parasitic disease resulting from the hydatid cyst of Echinococcus granulosus. It is described as a zoonotic disease and considered a neglected tropical infection. Conclusion: Biosynthesized AgNPs showed anti-hydatic effects and are suggested as anti-echinococcal cyst treatment
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