Assessment of the possibility of using dermal fibroblasts for reconstruction of oral tissue defects

Abstract

Relevance of the research topic.The regeneration of oral mucosa occurs without signifcant scarring, in contrast to skin wounds healing. Oral fbroblasts are characterized by the increased ability to replace and remodel the extracellular matrix (ECM) during wound healing, as compared to skin fbroblasts, together with the higher level of secretion of cytokines stimulating cells proliferation. The inflammatory reaction in oral mucosa injuries is less intensive than in skin wounds.Purpose.The goal is to review the literature on the topic to assess the possibility of using dermal fbroblasts for treating oral tissue defects Oral fbroblasts transplantation by injection or on various matrices signifcantly improves the recovery from periodontitis and gingival recession. Besides, positive effects of treatment can be achieved by using tissue substitutes containing autogenic oral fbroblasts and keratinocytes.Methods and materials.A review of the literature on the topic of 70 sources from them 12 domestic and 58 foreign data. Some researches demonstrate the key role of subepithelial tissue cells in the defnition of the upper epithelium cells properties.Results.At the same time, there are some reports about successful non-tissue-specifc transplantation, e.g. the treatment of oral mucosal defects by using tissue substitutes containing skin fbroblasts and keratinocytes.Summary.It is still unclear, whether skin-derived cells are suitable for stimulating the regeneration of oral injuries, further research required.