Abstract
The nose is one entrance to the respiratory tract, and as such serves an important defence function. Also, it has a particular relevance to clinical pharmacology which extends beyond the use of drugs for the treatment of local nasal disease. The nasal route of administration may be useful for drugs which are inactivated in the gastro-intestinal tract following oral administration, or where the intra-nasal route is an alternative to injection as with desmopressin and influenza vaccines (Freestone & Weinberg, 1976). In addition, because of the close resemblance of nasal mucosa to that elsewhere in the respiratory tract, the nose may be a useful model for the preliminary assessment of drugs which act within the respiratory tract such as anti-allergic agents, corticosteroids and even mucolytic drugs. It does not of course have bronchial smooth muscle, and its innervation differs from that of the bronchial tree.
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