Abstract
Introduction: Bacterial meningitis (BM) is a serious infection characterized by inflammation of themeninges, causing a high rate of acute complications in children. This research aimed to explain the effect ofprocalcitonin (PCT) in BM and its correlation with the others some inflammatory biomarkers.Method: The case-control study included Fifty children who were diagnosed with suspected bacterialmeningitis associated with febrile seizure according to the clinical investigation by specialized pediatricianand analysis of CSF and Forty children were enrolled as healthy control. The inflammatory biomarkersprocalcitonin, Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) were estimated for eachparticipants in addition to measurement of CBC(complete blood count) by using an automated instrument.Results: Patients have significantly higher serum levels of PRO, CRP, ESR, total WBC count, ANC, andNLR than the control group. Elevating serum PRO and CRP levels in patients group were significantlyassociated with increased serum ANC levels. A significant relationship was also observed between PRO andNLR, indicating that the PRO, CRP and NLR had a suitable biomarkers in the diagnosis of BM.Conclusion: Serum procalcitonin is more specific and sensitive inflammatory biomarkers than the NLR andCRP for the evaluation of suspected bacterial meningitis, so the recommended to use PCT assays in the earlydiagnosis of children with BM.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
