Abstract
OBJECTIVES: To determine and compare the serum lipid profile and uric acid concentration inpre-eclamptic and normal pregnant women.METHODOLOGY: This cross sectional study was carried out at Biochemistry Department, LUMHSJamshoro with the collaboration of Gynaecology and Obstetrics Department and Diagnostic & ResearchLaboratory, Pathology Department, LUMHS Jamshoro from March 2016 to December 2016. Patients wereselected via non-probability consecutive sampling. A total of 60 subjects were enrolled and divided intotwo groups comprising women with normal pregnancy(n=30) as controls and women with pre-eclampsia(n=30) as cases after applying exclusion criteria.RESULTS: Mean age of women with pre-eclampsia and normal pregnancy was found to be 26.77±2.58and 26.30±2.05 years (p-value=0.44). Significantly higher levels (p-value < 0.05) of triglycerides (TG), totalcholesterol (TC), low density lipoproteins (LDL) and serum uric acid were found in the women withpre-eclampsia as compared to controls; whereas, high density lipoproteins (HDL) were significantlylowered (p-value < 0.05) in women with pre-eclampsia. Uni-variate analysis showed that the TG(OR=7.67), TC (OR=3 and 5.55), LDL (OR=3.59) and uric acid (OR=11.23) were significantly increased andHDL (OR= 9.75) were significantly lowered in women with pre-eclampsia than in women with normalpregnancy (p-value < 0.05). In the multi-variate logistic model, TG (OR=4.28) and uric acid (OR=6.62)were significantly increased and HDL (OR= 4.31)were significantly lowered in women with pre-eclampsiathan in women with normal pregnancy (p-value<0.05)CONCLUSION: Alteration in the serum uric acid and TG concentration may be helpful in early detectionand monitoring of pre-eclampsia cases. This information may be utilized in preventing the adverseoutcomes occurring as a result of pre-eclampsia.
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