Abstract
The feasibility of blood-pool pinhole ECG gated SPECT was investigated in healthy mice to assess right and left ventricular function analysis. Anaesthetized (isoflurane 1–1.5%) adult CD1 mice ( n = 11 ) were analyzed after intravenous administration of 0.2 ml of 550 MBq of 99mTc human albumin. For blood-pool gated SPECT imaging, 48 ventral step and shoot projections with eight time bins per RR over 180° with 64 × 64 word images were acquired with a small animal gamma camera equipped with a pinhole collimator of 12 cm in focal length and 1.5 mm in diameter. For appropriate segmentation of right and left ventricular volumes, a 4D Fourier analysis was performed after reconstruction and reorientation of blood-pool images with a voxel size of 0.55 × 0.55 × 0.55 mm 3 . Average right and left ejection fractions were respectively 52 ± 4.7 % and 65 ± 5.2 % . Right end diastolic and end systolic volumes were significantly higher compared with the corresponding left ventricular volumes ( P < 0.0001 each ). A linear correlation between right and left stroke volumes ( r = 0.9 , P < 0.0001 ) was obtained and right and left cardiac outputs were not significantly different 14.2 ± 1.9 and 14.1 ± 2 ml / min , respectively. To cite this article: C. Goetz et al., C. R. Biologies 331 (2008).
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