Abstract
PurposeTo evaluate retinal volume in eyes without retinal disease using wide-field swept-source optical coherence tomography (SS-OCT). DesignObservational, cross-sectional design ParticipantsA total of 332 eyes of 166 healthy participants. MethodsThe eyes were imaged with OCT-S1 (Canon) using a protocol centered on the fovea cube scans (20 × 23 mm) of SS-OCT images. Retinal volume (6-mm circle, 6–20-mm ring) and various parameters were evaluated in a multivariate analysis using a generalized estimating equation model. Each quadrant of the macula except for the fovea (1–6 mm in diameter) and peripheral ring (6–20 mm in diameter) was also evaluated. Main Outcome MeasureRetinal volume ResultsIn the multivariate analysis, older age and longer axial length were associated with smaller macular retinal volume, whereas older age and left eye were associated with smaller peripheral retinal volume. The temporal area was significantly smaller than all other areas in the macula (1–6 mm), whereas the inferior area was significantly smaller than all other areas in the peripheral retina (6–20 mm). ConclusionsIn wide-field SS-OCT images, age and left eye are negatively correlated with peripheral retinal volume. The thinnest part of the retinal quadrant differs between the macular and peripheral retinas.
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