Abstract
BackgroundPreptin is a 34-residue pancreatic hormone that stimulates osteoblast proliferation and reduces osteoblast apoptosis.Research aimsTo measure levels of serum Preptin in rachitic children and in breastmilk of their mothers and to compare with levels in healthy non-rachitic children.MethodsThirty children with rickets and another 30 non-rachitic age and sex matched controls were subjected to detailed history, physical examination including anthropometric measurements, assessment of signs of rickets and laboratory measurement of serum vitamin D, calcium, phosphorus, alkaline phosphatase and Preptin. Mothers’ breast milk Preptin were also measured.ResultsSignificantly lower serum Preptin (p < 0.001) in rachitic children with a significant negative correlation between serum Preptin and alkaline phosphatase (P < 0.0001). Lower breastmilk Preptin levels in mothers of rachitic children (P < 0.001) with a negative correlation between breastmilk Preptin and both maternal weight and BMI(P < 0.01&P < 0.02). Mothers’ milk Preptin is positively correlated with serum Preptin and calcium in non-rachitic children(P < 0.001&0.04), but negatively correlated with their mothers’ age (P < 0.01).ConclusionPreptin may play a role in the etiology of rickets in children. Further studies are recommended to evaluate Preptin role in treatment of rickets in children.
Highlights
Preptin is a 34-residue pancreatic hormone that stimulates osteoblast proliferation and reduces osteoblast apoptosis.Research aims: To measure levels of serum Preptin in rachitic children and in breastmilk of their mothers and to compare with levels in healthy non-rachitic children
Preptin may play a role in the etiology of rickets in children
We found that mean serum Preptin in rachitic children was significantly lower than in healthy controls and this finding was close to the study of Ning, et al, and Ozkan et al, who documented lower levels of Preptin in patients with osteopenia and osteoporosis, with a positive correlation between bone mineral density(BMD) and Preptin levels [5, 17]
Summary
Preptin is a 34-residue pancreatic hormone that stimulates osteoblast proliferation and reduces osteoblast apoptosis.Research aims: To measure levels of serum Preptin in rachitic children and in breastmilk of their mothers and to compare with levels in healthy non-rachitic children. Preptin is a 34-residue pancreatic hormone that stimulates osteoblast proliferation and reduces osteoblast apoptosis. Preptin is a 34-residue pancreatic hormone synthesized primarily in the pancreas, salivary gland, mammary tissue, and kidneys [3]. It is shown to be anabolic to bone in vitro and in vivo and its bone activity resides within the [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16] N-terminal fragment of Preptin peptide. The truncated fragment of Preptin is enzymatically. Preptin stimulates osteoblast proliferation and reduces osteoblast apoptosis through the MAP-kinase pathway, and this leads to an increase in bone area and mineralization [5]. Previous studies reported low bone mineral densities to be associated with lower serum Preptin levels [5, 6]
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