Abstract

By August 2020, more than 850000 cases of new coronavirus infection (COVID-19) caused by SARSCoV-2 were confirmed in the Russian Federation, with the Rostov Region as one of the ten most affected regions in Russia. The spread of the disease is largely determined by the state of population immunity in a certain area. Our research focuses on specific humoral immune response and estimates the level of herd immunity to SARS-CoV-2 virus among the population of the Rostov Region.Materials and methods. The study involved 3,048 people; the volunteers participating in the study were divided into seven age groups. The content of antibodies to SARS-CoV-2 was determined applying ELISA using a kit for the analysis of human serum or blood plasma for the presence of specific IgG to the nucleocapsid of the SARS-CoV-2 virus, manufactured by the State Scientific Center of Applied Microbiology and Biotechnology (Obolensk) in accordance with the instructions for use.Results and discussion. The assessment of seroprevalence to SARS-CoV-2 in the Rostov Region showed that the proportion of people positive for IgG to the new coronavirus was 16.5 %, the range of seropositive individuals in the general population was between 13.9 % and 19.1 % (p<0.05). There were no significant gender differences in the degree of seroprevalence with a positive result registered in 16.6 % of women and 16.5 % of men. A high level of humoral immunity to SARS-CoV-2 was established in individuals aged 1–17 against the background of low incidence rates, which may indicate the dominance of asymptomatic forms of the disease in this age group. The highest level of seropositivity was found in preschool children (33.6 %), students (29.3 %), employees (17.3 %), and education professionals (15.3 %).

Highlights

  • Оригинальные статьи were no significant gender differences in the degree of seroprevalence with a positive result registered in 16.6 % of women and 16.5 % of men

  • The highest level of seropositivity was found in preschool children (33.6 %), students (29.3 %), employees (17.3 %), and education professionals (15.3 %)

  • В программе по оценке популяционного иммунитета приняли участие жители пяти городских округов Ростовской области, численность населения которых составляет 44,6 % от общего числа жителей области

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Summary

Original articles

Случаев заболевания новой коронавирусной инфекцией (COVID-19), вызванной SARS-CoV-2. Ростовская область вошла в число десяти наиболее пораженных регионов России. Распространение болезни во многом определяется состоянием популяционного иммунитета на определенной территории. Целью настоящего исследования являлись изучение специфического гуморального иммунного ответа и оценка уровня популяционного иммунитета к вирусу SARS-CoV-2 среди населения Ростовской области. Проведенная оценка серопревалентности к SARS-CoV-2 жителей Ростовской области показала, что доля лиц с положительными результатами теста на антитела IgG к новому коронавирусу составила 16,5 %, доля серопозитивных лиц в генеральной совокупности находится в пределах от 13,9 до 19,1 % (р

Материалы и методы
Результаты и обсуждение
Количество исследованных проб The number of examined samples
Дошкольники Preschool children
The number of examined sera
Число серопозитивных волонтеров
Findings
Список литературы
Full Text
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