Assessment of Mean Platelet Volume in Children with Celiac Disease on a Gluten-Free Diet

Aim: The purpose of this study was to evaluate mean platelet volume and platelet distribution width in children with celiac disease.Material and Methods: Fifty children with celiac disease (18 boys, 32 girls) and 63 healthy volunteer children (23 boys, 40 girls) were included in the study. Demographic features such as age, and gender and laboratory values such as platelet count, mean platelet volume, and platelet distribution width were recorded from the patients’ files.Results: Fifty children with celiac disease (18 boys, 32 girls) and 63 healthy volunteer children (23 boys, 40 girls) were included in the study. No statistically significant differences were determined between the celiac disease group and the healthy control group in terms of platelet counts (275,418±70,657/mm3 and 280,888±61,290/mm3, respectively, p=0.661), platelet distribution width (19.27±1.14 fL and 19.16±1.13 fL, respectively, p=0.670) or mean platelet volume (7.31±1.36 fL and 7.38±1.45 fL, respectively, p=0.779). At ROC analysis, a cut off value was determined for platelet distribution width of 18.2 fL with 24.00% sensitivity and 87.30% specificity (AUC: 0.504, 95% Cl: 0.408-0.599 and p=0.947). A cutoff value for mean platelet volume of 0.74 was calculated with 72.00% sensitivity and 44.44% specificity (AUC: 0.520, 95% Cl: 0.424-0.615 and p=0.708).Conclusions: Mean platelet volume values in children with celiac disease were no different to those of the healthy control group. We think that the absence of any change in mean platelet volume, values in children diagnosed with celiac disease may be related to a short duration of inflammation.

Assessment of red blood cell distribution width and mean platelet volume in children with epistaxis

BackgroundCeliac disease was thought to be uncommon, but now cases are prevalent worldwide. It is an autoimmune disease with the genetic susceptibility of the patient to gluten-containing food. The only...

Mean platelet volume in children with attention deficit hyperactivity disorder

BackgroundMean platelet volume (MPV), which is commonly used as a measure of platelet size, indicates the rate of platelet production and platelet activation. We aimed to evaluate the mean platelet volume in children with hepatitis A.MethodsIn this retrospective case-controlled study, the study population consisted of 62 children with hepatitis A and 62 healthy control subjects.ResultsMPV values, aspartate transaminase (AST), and alanine transaminase (ALT) levels on admission were significantly increased in patients with hepatitis A when compared to controls whereas white blood cell (WBC) counts were significantly lower. Two weeks after admission, the MPV values showed a significant decrease from 9.47 ± 1.62 to 8.84 ± 1.48 fL in patients with hepatitis A, but these values were still significantly higher than the controls. There was a significant difference in terms of MPV, WBC, AST, and ALT values between the controls and the patient group 2 weeks after admission.ConclusionsThis study is the first to evaluate the MPV levels in children with hepatitis A. MPV values were found to be increased in children hospitalized with hepatitis A.

I read the article by Arica et al. entitled ‘‘Evaluation of mean platelet volume in children with FMF’’ with interest. The authors cited one of our studies in reference number 17 (Makay B, Turkyilmaz Z, Unsal E. Mean platelet volume in children with FMF. Clin Rheumatol 2009;28:975–978). In the discussion part, in paragraph 3, they stated that ‘‘MPV values of attack-free FMF patients were found surprisingly less compared to those of healthy individuals.’’ However, this is not our result. We found that patients in acute attack had significantly lower MPV values than both healthy controls and attack-free patients. Besides, there was no difference between attack-free patients and healthy controls regarding the MPV. We kindly ask your help to correct this mistake. I also noticed that reference numbers are not in correct order. Reference numbers of 15, 16, and 17 should be checked out. Reference 15 corresponds to ‘‘Coban et al.’’ and Ref. 16 corresponds to ‘‘Makay et al.’’ in the last paragraph of introduction. However, ref. 15 becomes ‘‘Tunca et al.’’ in the first paragraph of discussion, and the other abovementioned references become 16, 17, respectively. Thank you for your help in advance.

Mean Platelet Volume in Children with Sickle Cell Disease on Chronic Transfusion Therapy.

Our aim is to investigate the correlation between the mean platelet volume (MPV) levels and platelet counts of the septic children with 28-day mortality risk. MPV at admission (MPV < sub > adm < /sub > ), MPV at 72 < sup > nd < /sup > hour (MPV < sub > 72h < /sub > ) and the difference between these two parameters (ΔMPV < sub > 72h-adm < /sub > ) and platelet counts were recorded retrospectively. The control group consisted of 100 healthy children matched for age, gender, and ethnicity. One hundred eighty six children were enrolled into the study. The study group had significant higher MPV values than those of control group. There were 156 survivors and 32 nonsurvivors in study group with a mortality rate of 17%. Nonsurvivors had significantly higher MPV < sub > adm < /sub > (p: 0.001), MPV < sub > 72h < /sub > (p: 0.001), ΔMPV < sub > 72h-adm < /sub > (p < 0.001) and lower platelet count (p: 0.002) than survivors. MPVadm (OR 2.39), MPV < sub > 72h < /sub > (OR 4.23), ΔMPV < sub > 72h-adm < /sub > (OR 6.4), platelet count (OR 7.3), and need for mechanical ventilation support (OR 9.76) had significant effect on 28-day mortality risk at logistic regression analysis. At the receiver operating characteristic analysis (ROC) the cutoff values for MPV < sub > adm < /sub > , MPV < sub > 72h < /sub > , and ΔMPV < sub > 72h-adm < /sub > were found to be 9 fL, 9.86 fL, and 0.79, respectively. Kaplan-Meier analysis and log-rank test proved that these cutoff values were significantly associated with the time of survival. Septic children who had high MPV levels at admission and whose MPV levels increased during follow up had higher risk of mortality. With the results of further researches targetting large groups of pediatric patients, MPV < sub > adm < /sub > , MPV < sub > 72h < /sub > , and ΔMPV < sub > 72h-adm < /sub > values can be fast and reliable markers for early diagnosis of sepsis and mortality prediction.

Platelets which are known to play a role in inflamation change their shapes when they are activated and this change is reflected in mean platelet volume and platelet distribution width values. Therefore, the mean platelet volume and platelet distribution width values are considered to be beneficial parameters for the diagnosis and treatment of many inflammatory diseases. The aim of the study was to evaluate platelet volume indices in children with acute bronchiolitis. A total of 514 infants who were below the age of 2 years old were evaluated in this study. Three hundred thirteen of these infants were diagnosed with acute bronchiolitis patients and 201 were healthy children. The patients were separated into four groups as mild, moderate, severe bronchiolitis and the control patient group. The groups were evaluated in terms of significant differences in the values of mean platelet volume and platelet distribution width. A p value of <0.05 was considered statistically significant for all results. The mean platelet volume was found to be 6.8±0.6 fL in the patients with mild bronchiolitis attack, 6.7±0.6 fL in the patients with moderate bronchiolitis attack, 6.5±0.5 fL in the patients with severe bronchiolitis attack and 7.3±1.1 fL in the control group. The mean platalet volume was statistically significantly lower in the mild, moderate and severe bronchiolitis attack groups compared to the control group (p=0.000). The platelet distribution width was found to be 17.2%±0.83 in the mild bronchiolitis attack group, 17.1%±0.96 in the moderate bronchiolitis attack group, 17.3%±0.87 in the severe bronchiolitis attack group and 16.9±1.6% in the control patient group. This difference was not statistically significant (p=0.159). The platelet count was statistically significantly higher in the mild, moderate and severe bronchiolitis attack groups compared to the control group (p=0.000). The mean platalet volume is decreased in patients with acute bronchiolitis. It is not a useful criterion in determining the severity of bronchiolitis attack. It is important that clinicians evaluating hemogram results to also interprete this variable.

Background Henoch-Schonlein purpura is a systemic small-vessel vasculitis that occurs mainly in children. A review of the literature has suggested a correlation between mean platelet volume and several inflammatory disorders. However, to the best of our knowledge, any potential correlation between mean platelet volume and Henoch-Schonlein purpura has not been reported in the literature. Therefore, our study aimed to evaluate the role of mean platelet volume concentrations in patients with Henoch-Schonlein purpura. Methods This study included 97 children with Henoch-Schonlein purpura and 120 healthy individuals as controls. Results Mean platelet volume concentrations were found to be significantly lower in Henoch-Schonlein purpura patients compared with healthy controls (8.1 ± 0.86 vs. 9.4 ± 0.81, P < 0.001). Similarly, significant negative correlations were observed between mean platelet volume and neutrophil count, platelet count and erythrocyte sedimentation rate in patients with Henoch-Schonlein purpura (r=-0.327, P = 0.001; r=-0.419, P < 0.001; r=-0.255, P = 0.012). Interestingly, mean platelet volume was significantly lower in the acute phase compared with the convalescent phase of Henoch-Schonlein purpura patients (7.8 ± 0.86 vs. 8.3 ± 0.77, P = 0.002). A cut-off value for mean platelet volume was 7.85 with area under the curve of 0.726 to identify acute phase vs. convalescent phase in patients with Henoch-Schonlein purpura. Mean platelet volume was independently associated with Henoch-Schonlein purpura in logistic regression analysis (odds ratio = 0.114, 95% confidence interval = 0.053-0.243, P < 0.001). Conclusions Our results suggest that mean platelet volume is inversely associated with disease in patients with Henoch-Schonlein purpura, and mean platelet volume may be a useful marker to identify active disease in Henoch-Schonlein purpura patients.

Increased mean platelet volume (MPV) is a manifestation of platelet functions and activation, and accepted as a prognostic biomarker in patients with cardiovascular disease. We aimed to investigate MPV levels in pediatric Famillial Mediterranean Fever (FMF) patients during the attack and attack-free periods, and the effect of colchicine treatment and presence of M694V mutation. Thirty-five pediatric patients with FMF and 38 age-sex-matched healty controls were enrolled retrospectively into the study. Of the patients 11 (31%) had an ongoing attack, and 24 (69%) were in attack-free period. 26 (74%) patients were receiving colchicine and 16 (45.7%) had M694V gene mutation. There was no significant difference in platelet (PLT) and MPV between patients and healthy controls (p=0.196 and p=0.167 respectively). Mean PLT and MPV values of the patients during attack and attack-free period were also not significantly different (p=0.355 and p=0.118 respectively). However, MPV levels during an FMF attack were non-significantly lower than healthy control group (p=0.08). PLT and MPV levels were higher in patients receiving colchicine but the differences were not significant (p=0.097 and p=0.446 respectively). Mean MPV value of the FMF patients with M694V mutation was not significantly different than controls (p=0.773). In conclusion, this study reveals that pediatric FMF patients have similar MPV levels with healthy individuals even in the presence of M694V mutation. MPV as an early atherosclerosis marker, is not significantly elevated in this patient cohort. Regular treatment with colchicine and younger age may have a role in non-impaired platelet activation in FMF patients

Objective: It has been suggested that mean platelet volume can be used as a marker of inflammation in some inflammatory diseases. This marker has not been investigated adequately in children with allergic disease. The aim of this study was to evaluate mean platelet volume in children with chronic spontaneous urticaria. Materials and Methods: Fifty-four children with chronic spontaneous urticaria (26 boys and 28 girls, mean age 13.70±3.66 years) were included in this retrospective study. The demographic characteristics, complete blood count, serum total IgE, erythrocyte sedimentation rate, and skin prick tests results of the patients were recorded. Sixty healthy children were included as the control group. Only complete blood count results of the control group were recorded. Platelet count, mean platelet volume, platelet distribution width, leukocyte count, and hemoglobin values were compared between the two groups. Correlations between mean platelet volume with age, disease duration, atopy, serum total IgE, and erythrocyte sedimentation rate were analyzed in the patient group. Results: There was no statistically significant difference in terms of age and sex between the two groups (p=0.09, p=0.60, respectively). Mean platelet volume and platelet count in the patient group were significantly higher than those in the control group (p=0.005, p=0.01, respectively). Platelet distribution widths in the patient group were significantly lower than those in the control group (p 0.05). Mean platelet volumes in the patient group were not correlated with age, disease duration, atopy, serum total IgE, and erythrocyte sedimentation rate. Conclusion: Mean platelet volumes and platelet counts are increased in children with chronic spontaneous urticaria. However, the mean platelet volume does not appear to be associated with the erythrocyte sedimentation rate and atopy.

Background: The contribution of platelets to the inflammatory response via several platelet derived mediators is well recognized. The role of mean platelet volume (MPV) in infectious and inflammatory disorders, however, has not yet been well-established. While some of the previous studies demonstrated that MPV acted as a positive acute phase reactant, several others suggested its role as a negative acute phase reactant. In the current study, we aimed to assess the role of MPV as an acute phase reactant in children with rotavirus gastroenteritis. Methods: We undertook a prospective, randomized, controlled, cross-sectional study and enrolled children diagnosed with acute rotavirus gastroenteritis and healthy controls (HC), between August and November 2012. Children with acute gastroenteritis were assigned either in the rotavirus-positive acute gastroenteritis (RPAG) or in the rotavirus-negative acute gastroenteritis (RNAG) group depending on their stool antigen results. Patients were also classified into two groups based on their Vesikari score (<11: non-severe and ≥11: severe). Complete blood count and C-reactive protein (CRP) levels were assessed for all patients. We compared MPV between RPAG, RNAG and HC groups and investigated the association, if any, among MPV, platelets, white blood count and CRP. Results: In total 100 RPAG (54 males; mean age: 38.74 ± 41.45 months), 100 RNAG (58 males; mean age: 32.84 ± 29.64 months) children and 100 HC (43 males; mean age: 33.21 ± 32.55 months) were enrolled into the study. Mean platelet counts were well-matched among groups (p > 0.05). We observed a steady decline in MPV (fL) in the HC, RPAG and RNAG groups (median 7.80, 7.35 and 7.30, respectively; p < 0.0001). We did not find an association between MPV and the clinical score of gastroenteritis (p > 0.05). Conclusion: We found that MPV could be used as an acute phase reactant in children with rotavirus gastroenteritis. We believe that the current study will contribute to our understanding of MPV as an inflammatory marker.

Juvenile idiopathic arthritis (JIA) is the most common chronic inflammatory arthritis in children. Mean platelet volume (MPV) is an indicator of platelet size and has been investigated as an inflammation marker in several diseases. This study was designed to investigate the MPV values in patients with JIA and healthy subjects, and determine the correlation between MPV, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). The hospital records of a total of 40 children with JIA, diagnosed using the International League of Associations for Rheumatology (ILAR) criteria, and 40 healthy controls were enrolled into the study. White blood cell count (WBC), platelet count, CRP, ESR, and MPV levels were retrospectively recorded. Children with JIA had significantly higher MPV values (8.28±1.12 fL) compared to the control group (7.53±1.07 fL) (p=0.003). Significant correlations were found between MPV, ESR, and CRP in the JIA group (r=0.676, p 0.05). Our results suggest that MPV levels may be a useful marker of inflammation and prognostic factor for atherosclerosis risk in pediatric JIA patients.

To evaluate the Mean Platelet Volume (MPV) levels in children diagnosed with familial Mediterranean fever (FMF), during attack and attack-free periods. The records of a total of 117 children with FMF, diagnosed using the Tel-Hashomer criteria, have been scanned. The study consisted of 53 patients during an attack (group 1), 64 patients in attack-free period (group 2), and 57 healthy controls (group 3). Erythrocyte sedimentation rate, C-reactive protein, white blood cell count, platelet count, and MPV levels were retrospectively recorded. The MPV and platelet values in FMF patients during attack (group 1) and FMF patients during attack-free periods (group 2) have been found to be significantly higher than those of the health control group (group 3). Positive correlation has been found between the MPV and platelet values in Group 1 and the disease's severity score (r = 0.224, and r = 0.268, respectively). Positive correlation (r = 0.528, and r = 0.485, respectively) has been also identified between MPV and blood platelet count in patients in Group 1 and 2. No correlation was found between the Colchicine treatment period and MPV (r = -0.005). The MPV values in the complete group of FMF diagnosed children have been found to be much higher compared to those in healthy children. As a consequence, we consider the MPV value as a useful marker that demonstrates the risk of early stage atherosclerosis in children with FMF.