Abstract
ABSTRACTOBJECTIVE: Blood biomarkers for diseases have recently become a topic of great interest. Many studies of Autism Spectrum Disorder (ASD) have been made to date looking for biomarkers in peripheral tissues, but no specific biomarker has yet been found. The aim of this study was to examine oxidative stress parameters including malondialdehyde (MDA) levels, superoxide dismutase (SOD), and catalase (CAT) activity and to determine both their sensitivity and specificity as biomarkers associated with oxidative stress in ASD.METHODS: This study measured the plasma MDA levels, SOD, and CAT activities in erythrocyte in 52 patients with ASD (aged 3–6 years) and in 48 age- and gender-matched healthy controls. ASD severity was rated using the Childhood Autism Rating Scale (CARS).RESULTS: MDA levels, SOD, and CAT activity were significantly higher in patients with ASD in comparison to the controls (p < .001). The receiver operator characteristic curve analysis showed a high diagnostic value for MDA, SOD, and CAT...
Highlights
According to the classification in the Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-V), autism spectrum disorder (ASD) is a neurodevelopment disorder characterized by impaired reciprocal social communication skills and social interaction, and by limited and repetitive patterns of behaviour, interests, or activities [1]
The main finding of our study has indicated that there was an increase in MDA levels, superoxide dismutase (SOD) and CAT activity in children with ASD compared to the controls
Increased levels of lipid peroxidation and decreased levels of serum ceruloplasmin and transferrin indicate that ASD children have a higher level of oxidative stress, which is most probably caused by the abnormal metabolism of pro-oxidant metal ions and/or decreased antioxidant proteins [25]
Summary
According to the classification in the Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-V), autism spectrum disorder (ASD) is a neurodevelopment disorder characterized by impaired reciprocal social communication skills and social interaction, and by limited and repetitive patterns of behaviour, interests, or activities [1]. It has been suggested that genetic susceptibility, immunological alterations, and environmental factors might play an etiopathogenic role in ASD [2,3,4,5]. There are currently no accepted biomarkers for diagnosis and/or screening, meaning that ASD diagnosis is made only on the basis of clinical findings [6]. Young children with ASD can benefit a great deal if therapy is given early on. Such benefits include fewer ASD symptoms and corresponding maladaptive disorders, which in turn can lead to better results [7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
