Assessment of LV systolic function using cardiac time intervals with an acoustic array approach

Abstract

Introduction Cardiac time intervals (CTIs) are sensitive markers of cardiac hemodynamics, and have previously been demonstrated to contain prognostic information consistent with conventional echocardiographic parameters. As LVEF decreases, aortic valve opening (AO) is delayed relative to ejection time (ET). HEMOTAG is the first known device to provide hemodynamics wirelessly via a smartphone using cardiac vibrations and an ECG signal transducer via multiple anterior chest wall electrodes. The purpose of this study was to assess LV function using CTIs from echo and HEMOTAG. Methods Within a 4 months period, 136 consecutive patients undergoing TTE were recruited at an outpatient office. CTIs by HEMOTAG and Echo along with TTE and cardiologist reports were recorded. Heart failure (HF) was characterized from echo variables according to standards from the 2016 ASE. Patients with reduced LVEF ( Results A total of 110 patients had normal LVEF, while 26 patients had reduced LVEF. Among patients with normal LVEF, 43 had normal diastolic function, 31 had diastolic dysfunction and 36 had indeterminate HF. Figure 1 shows STR mean±SE for each HF group and CTI instrument. Mean STR for HFrEF patients was significantly higher than normal, HFpEF and indeterminate patients (F(3,239) = 26.58, p Conclusions STR from Echo and HEMOTAG successfully predicted reduced LVEF in a population of HF patients. Diastolic HF severity/progression was predicted by increasing AC from both Echo and HEMOTAG and from Echo ET. Our results also showed the effect of age on Echo and HEMOTAG measures which should be accounted for when interpreting measures for HF diagnosis.