Abstract
Atherosclerosis of large and medium sized arteries are believed to be the major reason behind the development of Coronary Artery Diseases and Hyperlipidemia has been found to be one of the most important contributing factors. Appropriate lifestyle changes along with proper drug therapy lead to a considerable reduction in mortality rate due to coronary artery disease. Reduction of LDL Cholesterol is the primary goal of cholesterol-lowering therapy, but most of the patients are usually unable to achieve the treatment goals with lifestyle modifications alone; and in such situations, drug therapy is essential to prevent the disease progression and further future complications. The aim of the study was to demonstrate impact of three moderate intensity statins on lipid profile and biomarker representing muscle toxicity. It was a prospective observational study conducted in a tertiary care teaching hospital in south India. Patients of both gender falling the age group between 30 and 70 years with newly diagnosed Hyperlipidemia attending the Department of Medicine OPD, were enrolled in the study. Total 229 participants were enrolled in study and all the drug treatment were found to be effective in achieving the treatment goal; at the same time Rosuvastatin 10 mg treatment group exhibited better efficacy along with minimal muscle toxicity.
Highlights
Cardiovascular diseases (CVD) are those abnormal conditions related with the heart and blood vessels, which is considered as one of the leading causes of morbidities and mortalities worldwide [1]
The result from the current study indicates the prominent role of Atorvastatin 20 mg among moderate intensity statin drugs in management of Hyperlipidemia
The present study was aimed to assess the impact of moderate intensity statin therapy on lipid profile and creatinine kinase in newly diagnosed hyperlipidemia patients
Summary
Cardiovascular diseases (CVD) are those abnormal conditions related with the heart and blood vessels, which is considered as one of the leading causes of morbidities and mortalities worldwide [1]. The overall risk for CVD starts for an individual at their young age without a known risk for CVD, Coronary heart disease (CHD) accounts for approximately one-third to one-half of the total cases of CVD [2]. The most common CVDs are hypertension, coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease [3]. Hypertension, hyperlipidemia, diabetes, obesity, sedentary lifestyle, improper diet, alcohol consumption and tobacco use are considered to be the modifiable risk factors leading to CVDs. Among them hyperlipidemia, diabetes, hypertension, obesity, and smoking are identified to be accountable for more than half of CVD mortality [4]. Cholesterol transportation in the body is made with the help of lipoproteins and there are two types of lipoproteins: LDL leads to an upsurge of cholesterol in arteries and HDL transports the cholesterol from various part of the body back to the liver [5]
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