Abstract
ObjectiveThe purpose of the present investigation is to rule out the antacid activity of Tephrosia purpurea root by in vitro method using a self fabricated and modified artificial stomach model. The reason for selecting in vitro method was to minimize the usage of experimental animals. MethodIn this work we have used air bubbles from an aerator to mimic the peristaltic movements of stomach. Sodium bicarbonate and water were used as reference and control respectively. The parameters evaluated were neutralizing effect, duration of neutralization effect and capacity and effect of temperature on pH. We evaluated the potency of the plant by extracting with three solvents in increasing order of polarity. ResultsThe neutralization effect, duration of neutralization effect and capacity were found to be higher for methanol root extract than sodium bicarbonate, whereas ethyl acetate and chloroform extract produced moderately good response but less when compared to standard drug but higher than water. ConclusionHence this plant can be an effective alternative for sodium bicarbonate which is reported to have side effects like edema n the feet, alteration in systemic pH, belching etc.
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