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Abstract
Background: Sickle-cell anemia (SCA) results from a point mutation, in which an adenine nucleobase in the sixth codon of the globin gene is replaced by a thymine (GAG GTG). The immune-inflammatory system is a complex network of cells and humoral elements that includes many cytokines. Cytokines are peptides used by cells for intercellular communication and for controlling the inner environment of the cells in which they operate. They are produced by cell types that have important roles in the immune response, inflammation, haemopoiesis, healing and systemic response to injury. Aim: The aim of this study was to assess serum levels of IL-2, IL-10 &TNF in sickle cell disease anemia subjects placed on selenium supplements in their steady state. Methods: This is a cross- sectional study. A total of fifty aged matched participants were recruited for this study. 50 SCA subjects with sickle cell anemia (SS) were placed on selenium supplements 200mcg for 90 days.IL-2,1L-10& and TNF were measured using enzyme linked immunosorbent assay (ELISA) method. Results: The result showed that the mean serum level of IL-2, (119.0621.68), significantly reduced while IL-10 and TNF (119.5919.20 and 16.232.83) significantly increased. Significance at (p0.05) after administration of selenium supplements while compared with the baseline values (125.0642.68, 116.4517.30 and 15.963.32) respectively. Conclusion: SCA is a well-studied monogenetic disease with an established chronic inflammatory component. IL2 is a pro-inflammatory cytokine while both IL 10 and TNF are both anti-inflammatory cytokines. The intake of selenium supplement helped in suppressing the proinflammatory mediator while the protypical anti-inflammatory cytokine stepped their activities.
Published Version
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