Abstract
This study aimed to investigate the relationship between indications and histopathological results in patients undergoing endometrial sampling. Data of 4,247 patients undergoing endometrial sampling due to non-obstetric gynecological causes between January 2010 and October 2016 were retrospectively evaluated using the archives of the Gynecology and Obstetrics Clinic of Konya Training and Research Hospital. The mean age of patients was 46.8 ± 8.22 years; the most common indication was menometrorrhagia/menorrhagia (70.66%), and the least common indication was cervical polyp (1.34%). The most common histopathological result was proliferative-secretory endometrium (63.62%); simple hyperplasia with atypia (0.56%) was determined to be the least common result. Endometrial cancer was observed more frequently in the post-menopausal bleeding and increased endometrial thickness group (23.11%). Of patients in whom biopsy was performed, 52.18% had undergone hysterectomy, as a result of which proliferative-secretory endometrium was most commonly (59.52%) and simple hyperplasia with atypia least commonly found as the histopathological diagnosis. Although sampling should be performed following endometrial evaluation in patients with post-menopausal bleeding or increased endometrial thickness, according to the results of our study, routine endometrial biopsy should not be preferred in the other indications.
Highlights
Abnormal uterine bleeding is among the most common causes of admissions to gynecology clinics, and it is of great importance as it is the most common sign of anemia in the pre-menopausal period and suspicion of malignancy in the post-menopausal period
Hysteroscopy is accepted as the gold standard for evaluating endometrial pathologies as the endometrial cavity may be directly observed with hysteroscopy, which enables concurrent treatment [3, 6]
Recent studies report that routine endometrial sampling is controversial as they are associated with high costly, high morbidity, and anxiety in patients [5,6,7]
Summary
Abnormal uterine bleeding is among the most common causes of admissions to gynecology clinics, and it is of great importance as it is the most common sign of anemia in the pre-menopausal period and suspicion of malignancy in the post-menopausal period. Endometrial sampling, which is widely used for the diagnosis and treatment of endometrial pathologies, is performed using dilation curettage (D/C), aspiration (office biopsy), and hysteroscopy methods [3]. Ozturk Inal et al Endometrial Sampling Requirement 45 in 1843 and was widely used, is used less commonly due to its requirement of anesthesia, high morbidity, perforation risk, and high cost [1, 3]. Sampling methods such as Pipelle, which is easier, inexpensive, and can be used under office conditions are preferred [4]. Recent studies report that routine endometrial sampling is controversial as they are associated with high costly, high morbidity, and anxiety in patients [5,6,7]
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