Abstract
Ficus religiosa is a medicinal plant and scientifically documented for the pharmacological activities like antidiabetic, anti-inflammatory, antipyretic, etc. The present study was planned to investigate the antiulcer activity of ethanol extract of Ficus religiosa fruit in pylorus ligated and aspirin induced ulceration in experimental animals. The ethanol extract of fruits of Ficus religiosa were prepared by maceration. The antiulcer activity of ethanol extract were evaluated by using pylorus ligated and aspirin induced ulceration models. The administration of ethanol extract of ethanol extract of Ficus religiosa at the dose of 200 mg/kg and 400 mg/kg significantly decreased the ulcer index, pH, gastric volume, free acidity and total acidity compared to control group. The findings proposed the antiulcer activity of ethanol extract of Ficus religiosa fruit.
Highlights
Peptic ulcers are a broad term that includes ulcers of digestive tract in the stomach or the duodenum
Antiulcer activity of ethanol extract of fruit of Ficus religiosa was evaluated in pylorus ligated and aspirin induced ulceration in experimental animals
The animal treated with aspirin significantly increased the ulcer index, pH, gastric volume, free acidity and total acidity compared to normal group
Summary
Peptic ulcers are a broad term that includes ulcers of digestive tract in the stomach or the duodenum. It is characterized by the disruption of the mucosal integrity of the esophagus, stomach, or duodenum[1]. Bark of the plant is used as gonorrhoea, diarrhea, dysentery, cervical cancer, epilepsy, leucorrhea, menorrhagia,vaginal and other urogential disorders haemorrhoids, ulcers, skin diseases and gastrohelcosis. It is useful in inflammation, anti-anxiety, burning sensation, anti-bactrial, analgesic, anti-diabetic and antioxidant[11,12,13]. It was planned to evaluate the antiulcer activity of ethanol extract of Ficus religiosa fruit in pylorus ligated and aspirin induced ulceration in experimental animals
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