Abstract
Abstract. In the present work, the evaluation of the antimicrobial activity of Diplostephium phylicoides and Diplostephium revolutum on different microorganisms was carried out on using bacteria such as Escherichia coli (CMPUJ:034), Staphylococcus aureus (CMPUJ:370), Salmonella typhi (CMPUJ:045) and Pseudomonas aeruginosa (CMPUJ:065), yeasts such as Saccharomyces cerevisiae (CMPUJ:H042) and Candida albicans (CMPUJ:H022), and filamentous fungi such as Penicillium chrysogenum (CMPUJ:H061) and Aspergillus niger (CMPUJ:H002). This assessment was made by the method of plates and wells using extracts from the leaves of the previously mentioned plants. The extracts were made with different solvents, ethanol, ethyl acetate, dichloromethane and petroleum ether. The results showed that the ethyl acetate extract of Diplostephium phylicoides has antimicrobial activity against Staphylococcus aureus and Candida albicans; furthermore, the dichloromethane extract showed an inhibitory effect against Saccharomyces cerevisiae. When comparing the extracts of the two plants, under the evaluated conditions, the extracts presented antimicrobial activity, and the ethyl acetate extract of Diplostephium revolutum the one that showed better activity against all the microorganisms.
Highlights
According to the World Health Organization, antibiotic resistance is increased by the misuse and abuse of drugs, as well as with the deficiencies in the prevention and control of infections [1]
We evaluated the antimicrobial activity of leaf extracts from D. phylicoides and D. revolutum plants against Escherichia coli, S. aureus, Salmonella typhi, and Pseudomonas aeruginosa bacteria; Saccharomyces cerevisiae and Candida albicans yeasts; and the filamentous fungi Penicillium chrysogenum and Aspergillus niger
The negative control showed no antimicrobial activity against the study microorganisms, while the positive controls showed antimicrobial activity, which was variable depending on the microorganism
Summary
According to the World Health Organization, antibiotic resistance is increased by the misuse and abuse of drugs, as well as with the deficiencies in the prevention and control of infections [1]. Phytomedicines are identified as a viable option, because plants, in their survival nature, produce secondary metabolites such as terpenes, phenols, flavonoids, quinines, tannins, and alkaloids [2]. These are obtained by making plant extracts, which have been identified to possess antimicrobial activity and have been previously used for the production of phytomedicines, which like synthetic drugs, are able to treat, cure, or alleviate diseases. Phytomedicines represent a great opportunity since it is possible to develop them with endemic plants, which are exclusive to a region For this reason, it is important to identify the plants that produce the secondary metabolites required to guarantee effective phytomedicines. Some native plants that may exhibit these properties belong to the genus Diplostephium [3,4,5]
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