Abstract
Ultrasound (US) acts synergistically with recombinant tissue plasminogen activator (rt-PA) to accelerate thrombolysis. A correlation between clot mass loss and production of the fibrin degradation product D-dimer was investigated using an in vitro clot thrombolysis model. Fully retracted clots formed from 1.5-ml human whole blood were suspended in plasma at 37°C and treated with rt-PA, or rt-PA, Definity®, and pulsed 120-kHz US for 30 min. Clots in plasma alone served as controls. Thrombolytic efficacy was assessed as percent clot mass loss. Samples from plasma surrounding the clot and from macerated clots were analyzed for D-dimer using an enzyme linked immunosorbent serologic assay. A statistically significant enhancement in clot mass loss was observed for clots exposed to rt-PA, Definity®, and US compared to rt-PA alone. Clots treated with rt-PA exhibited a higher concentration of D-dimer both in the clots and plasma. However, clots treated with rt-PA, Definity®, and US did not exhibit an enhanced leve...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
