Abstract
In the current issue of Biological Psychiatry, Sigvard et al. (1) report on a model study of striatal dopamine synthesis (DS) in schizophrenia that has many strengths. First, they used a technically challenging positron emission tomography imaging technique and developed a new, more precise analytic approach to calculate DS. Second, they discarded the widely used tissue reference model, weighted down with significant assumptions, for an advanced approach in which they used new parameters to calculate DS and k3 in a 4-parameter model.
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