Abstract
Objective: Renal volume-based estimates of glomerular filtration rate (GFR) using computed tomography (CT) in renal donor populations have been described. We hypothesized that the same technology would be especially useful in myelomeningocele (MMC) patients for whom standard methods of GFR assessment are inaccurate. Methods: 13 adult subjects with MMC for whom we had CTscans of the abdomen and pelvis with contrast were identified. 125 I-iothalamate studies were available for 2 of the 13 subjects. Renal volumes were calculated from CT-scans using a fitted regression model which has been previously validated in a renal donor population. A volumetric-based GFR was then calculated. Correlation between renal volume-based GFR and Modification of Diet in Renal Disease (MDRD) and Cockcroft-Gault (C-G) GFR was calculated. Results: Correlation between volume-based GFR and MDRD GFR was +0.76 (p = 0.003) while the correlation between volume-based GFR and C-G GFR was +0.68 (p = 0.010). Volumetric-based GFR was higher than 125I-iothalamate based estimates for the 2 patients for whom we had
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