Assess the Clinical Significance of Serum CEA and CA 19-9 in Patient with Gastric Cancer

Abstract

Background: Gastric cancer is a leading cancer in Bangladesh as well as a cause for cancer related mortality like that of other Asian countries. Gastric cancer can be a curable disease provided that it is detected at an early stage and treated adequately. Gastric cancer usually does not disseminate prior to involving lymph node, so there is an opportunity to cure the disease before dissemination. Unfortunately, there are many cases where gastric cancer presents as a late case and cause of poor overall survival. Tumor markers are assuming a promising role in various stages of cancer case, which starts from screening to follow up after treatment. Judicial application of Tumor markers in clinical practice need knowledge about the role of tumor markers in any given malignancy. Objectives: To assess the clinical significance of serum CEA and CA 19-9 in patient with gastric cancer. Material & Methods: This was a Cross-sectional Observational Study. This study carried out in the Department of Surgery, Dhaka Medical College Hospital (DMCH), Dhaka, Bangladesh. During the Study period of January, 2017 to December, 2017 (12 months), a total of 54 patients of highly suspected for gastric cancer were enrolled in the study. All patients with history, sign-symptoms and clinical examination suggesting gastric cancer attended in Surgery Department of DMCH for treatment. The patients with gastric cancer were diagnosed by endoscopy and confirmed by biopsy. Purposive sampling (non-randomized) was done according to availability of the patients and strictly considering the inclusion and exclusion criteria. The optimal cut off point for CEA and CA19-9 in gastric cancer patients was determined by using ROC. Statistical analyses were carried out by using the Statistical Package for Social Sciences version 23.0 for Windows (SPSS Inc., Chicago, Illinois, USA). Chi-Square test was used to analyze the categorical. Results: CEA and CA 19-9 marker levels are useful in the preoperative ...........