Abstract
We synthesized DNA-cholesterol conjugate molecules and introduced them into 1-palmitoyl-2-oleoyl-sn-3-phosphocholine (POPC) liposomes to create DNA-tagged liposomes. These liposomes aggregated selectively depending on the sequence of DNA tag and the resultant pattern of the aggregation was a wide-spreading network structure, which was observed under a phase contrast microscope. The structure was minutely analyzed by transmission electron microscopy (TEM) and confocal laser-scanning microscopy. As a result, a hierarchical structure of the amphiphilic molecules was constructed from the liposome to the network via clustered structures.
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