Abstract
Increased output of urinary total free catecholamines assayed by the trihydroxyindole method has been found in patients suffering from tetanus treated with pancuronium. These increases did not correlate with elevations or fluctuations in systolic blood pressure. Total free catecholamines were decreased or undetected in the urines of patients with tetanus treated for a prolonged period with large doses of tubocurarine. Recovery of noradrenaline added to the urine of these patients was either diminished or absent. Tubocurarine added to normal urine in concentrations up to 100 μg per μg of noradrenaline did not interfere with the fluorimetric estimation of noradrenaline. It is suggested mat the prolonged administration of tubocurarine to patients with tetanus leads to the development of a factor which interferes with the production of catecholamines and prevents the detection of catecholamine fluorimetrically in the urine.
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