Abstract
Objective To explore the effects of peridopril on vascular inflammation and vascular endothelium function in mild to moderate essential hypertensive (EH) patients. Methods 140 EH patients were divided into peridopril group (70 cases) and conventional treatment group (70 cases). 70 cases of healthy volunteers were selected as a control group. We examined the blood express levels of high sensitivity C-reactive protein(hs-CRP), IL-6, ICAM-1, Fibrinogen C(FIB-C)and endothelium 1 (ET-1), nitric oxide (NO) levels and flow mediated dilatation (FMD) in brachial artery blood samples as well as angiotension before beginning treatment in each group, The peridopril group received a 4 mg tablet daily for 4 weeks. in addition to similar drug therapies as those in the conventional treatment group. Results All EH patients9 blood levels of hs-CRP, IL-6, ICAM-1, FIB-C and ET-1 increased significantly (all p Conclusions Peridopril tablet can inhibit vascular inflammation and protect the vascular endothelium function of EH patients. It is likely this plays an important role in the prevention of thrombotic diseases induced by hypertension.
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