Abstract
This is the first report in which aspirin (ASA) has failed to inhibit aggregation of mammalian platelets. Preincubation of citrated sheep platelet rich plasma with a final concentration of 500 μM ASA for 3 minutes at 37°C did not inhibit aggregation induced by either arachidonic acid (AA; 1.6 mM), ADP (2.5 μM), collagen (5.6 μg/ml) or thrombin (0.04U). Instead, ASA potentiated the aggregation response produced by these agents except AA. Platelet aggregation that was reversible with ADP became irreversible after adding ASA. The inhibitory properties of ASA was confirmed with human platelets, challenged with AA, ADP, adrenalin and collagen. These findings suggest that sheep platelets have an ASA resistant cyclo oxygenase and may be able to aggregate by a pathway that is independent of arachidonic acid.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
