Abstract

As the director of one of the largest evaluation and treatment centers for patients with aspirin-exacerbated respiratory disease (AERD) in the world, I am often asked on how we should approach the use of aspirin desensitization followed by high-dose aspirin therapy for our patients with AERD in the current age of newly available biologics. I feel strongly that, at least for now, there is a place for both treatment modalities, sometimes even both in the same patient at the same time. In the end, it is always a set of decisions that need to be made on an individual patient basis, and I consider the following 4 general domains when approaching the decision and my recommendation: efficacy, safety, cost, and patient preference.

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