Abstract
Acetylsalicylic acid (aspirin) alters platelet function, causing impairment of small vessel hemostasis and prolongation of the bleeding time. This effect may exacerbate hemorrhage and also suggests a role for this drug as an antithrombotic agent. Normal subjects were treated with different doses of aspirin for periods of two weeks. As little as 325 mg. of acetylsalicylic acid each day resulted in a stable prolongation of the template bleeding time. Two normal subjects received 325 mg. daily for 3 months. Their bleeding times remained prolonged throughout this period, correlating with the abnormality of platelet aggregation characteristic of aspirin ingestion. The template bleeding time is a simple technic for monitoring the effect of aspirin on platelet function and is an aid for further research in therapy for thrombotic conditions.
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