Abstract
Department of Pharmaceutical Engineering, Woosuk University, Wanju, 565-701, Republic of Korea (Received December 13, 2010. Accepted December 21, 2010)ABSTRACT: A homothallic filamentous fungus Aspergillus nidulans has been used as the a model organism forstudying growth and development for eukaryotic system. Various studies about specific transcription factors havebeen performed for elucidating the molecular mechanisms of growth, asexual and sexual developmental processes.Among them, the fkhE gene (AN2025.3) is located in chromosome VII and contains an ORF encoding 718 aminoacid polypeptide intervening with two short introns. The cDNA sequencing revealed that at least four types of alter-native splicing events were occurred when the fkhE gene was transcribed. The putative FkhE polypeptide containsa conserved forkhead domain and a bipartite nuclear localization signal at it's N-terminus and C-terminus, respec-tively. Deletion of fkhE resulted in impaired conidiophore formation in a solid medium. However, the sexual devel-opmental process or cleistothecia formation was normal. Furthermore, fkhE deletion mutant produced conidiophoresand conidia under the submerged culture, indicating that the fkhE gene is involved in asexual developmental processsimilar to the fkhF gene.KEYWORDS :
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