Asemptomatik Hipertansif Hastalarda Parçalanmış QRS Kompleksi ile Arteryel Komplians Arasındaki İlişki

Abstract

Objective: Decreased arterial compliance is among the earliest detectable findings of adverse structural and functional changes in the vessel wall and it results in stiffened arteries. The goal of this study was to explore the relationship between fragmented QRS in electocardiogram and arterial compliance.Material and Methods: Eighty asymptomatic hypertensive patients with fragmented QRS (40 male, mean age: 58±8/years) and 80 age-gender matched control subjects without fragmented QRS (39 male, mean age: 57±9/years) were enrolled. Arterial compliance was calculated as stroke volume to pulse pressure ratio and adjusted to body surface area to calculate the stroke volume to pulse pressure index. The fragmented QRS complexes were investigated in the 12-lead electrocardiogram.Results: Patients wih fragmented QRS had significantly lower arterial compliance (0.71±0.29 mL/m2/mmHg versus 0.93±0.32 mL/m2/mmHg; p<0.001). A univariate analysis showed a significant correlation between decreased arterial compliance and fragmented QRS, age, and calcium channel blocker use. Multivariable analysis demonstrated age (95%CI): 0697-0.830; p<0.001) and fragmented QRS (95%CI): 0.06-0.536; p=0.002) as independent determinants of reduced arterial compliance.Conclusion: The avaliability of fragmented QRS in electrocardiogram may have significant predictive information of arterial compliance in hypertensive subjects.