Abstract
Ascorbic acid, the reduced form of vitamin - C, is secreted by the normal stomach and may protect against gastric carcinoma and peptic ulcera-tion . This study examined the effect of helicobacter Pylori (H.P) on the secretion of ascorbic acid into gastric juice and examined if H.P. eradication improves gastric juice ascorbate values. Eighty six patients with dyspeptic symptoms were included into the study. Fasting plasma and gastric juice ascorbic acid measurement, anti H.P. IgG, rapid urease slide test and bacteriological examination for antral & corpus biopsy specimens during endoscopy were done for all patients at entery into the study. Gastric juice ascorbic acid concentrations in H.P. positive patients were significantly lower (374.9±66.6 micromol/dl) than those in 10 H.P. negative controls, (507.8±9.04 micromol/dl] (P<0.0001). Likewise, plasma ascorbic acid concentrations in H.P. positive patients were significantly lower (322.7 ± 92.2 micromol / dl) than those of H.P. negative control (513.1 ± 17.5 micromol /dl) (P<0.0001). Of the 76 H.P positive patients who received one - week triple therapy (Omeprazol, Amoxicillin & Metronida-zole), H.P. was successfully eradicated in 66 (86.8%), and after one month, their mean gastric juice ascorbic acid concentrations rose to 453. + 76.01 micromol/dl (P< 0.0001) and their mean plasma ascorbic acid concentration rose to (419.3± 104.4 mi)
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