Abstract
Catalase (CAT) is part of the enzymatic defense system against reactive oxygen species (ROS), known to be involved in the pathogenesis of asbestosis. This study investigates whether CAT -262 C>T genetic polymorphism influences the risk of asbestosis in workers occupationally exposed to asbestos.The nested case-control study included 262 cases with asbestosis and 265 controls with no asbestos-related disease. Data on cumulative asbestos exposure and smoking were available. A real-time PCR assay was introduced for genotyping CAT -262 C>T promoter polymorphism.A slightly elevated risk of asbestosis was observed in subjects with the CAT -262 TT genotype compared to others (OR=1.36, CI 0.70-2.62). This risk did not change substantially after adjustment by sex, age, and smoking, but the involvement of cumulative asbestos exposure changed the OR to 1.91 (CI 0.93-3.91). These findings indicate that the CAT -262 TT genotype may be slightly associated with an increased risk of asbestosis. No synergistic effect was found between cumulative asbestos exposure and the CAT -262 TT genotype, but cumulative asbestos exposure acted as a confounder. These results are an important contribution to understanding the interactions between genetic and environmental factors that may modify the risk of asbestosis.
Highlights
Catalase (CAT) is part of the enzymatic defense system against reactive oxygen species (ROS), known to be involved in the pathogenesis of asbestosis
To thoroughly investigate the interactions between genetic and environmental factors that could influence the risk of asbestosis, we designed a series of studies focusing on the most common polymorphisms of metabolic enzymes involved in the antioxidant response and xenobiotic detoxification in a large cohort of workers occupationally exposed to asbestos from a small geographic area with an ethnically homogenous population [32]
Several studies have investigated the influence of genetic polymorphisms of metabolic enzymes on the risk of asbestosis, mostly focusing on the polymorphisms of glutathione S-transferases (GSTs) M1, T1, P1 (GSTM1, GSTT1 and GSTP1), and manganese superoxide dismutase (MnSOD) [7,8,9,10, 30,31, 40]
Summary
The results of several studies suggest that reduction in catalase activity may play an important role in the host response to oxidative stress, and could be associated with increased risk of certain diseases [23,24,25,26]. To thoroughly investigate the interactions between genetic and environmental factors that could influence the risk of asbestosis, we designed a series of studies focusing on the most common polymorphisms of metabolic enzymes involved in the antioxidant response and xenobiotic detoxification in a large cohort of workers occupationally exposed to asbestos from a small geographic area with an ethnically homogenous population [32]. This study investigated the influence CAT -262 C>T polymorphism on the risk of asbestosis in workers occupationally exposed to asbestos
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