Current Organic Synthesis | VOL. 19

Arylidenemalononitriles as Versatile Synthons in Heterocyclic Synthesis

Publication Date Aug 1, 2022


Background: Arylidenemalononitriles are valuable synthons for the construction of a variety of novel complex heterocyclic motifs, fused heterocycle derivatives, and spirocyclic com-pounds. They are versatile chemical intermediates and have increasing applications in industry, agriculture, medicine, and biological science. Objective: The aim of this review is to highlight the preparation methods and reactions of aryli-denemalononitriles in the synthesis of various heterocyclic compounds. Conclusion: In this review, we have presented the application of arylidenemalononitriles to con-struct a variety of heterocycles. Various catalysts for the preparation of arylidnemalononitriles have been described.


Synthesis Of Various Heterocyclic Compounds Versatile Chemical Intermediates Spirocyclic Com-pounds Versatile Synthons Applications In Industry Heterocyclic Synthesis Heterocyclic Compounds Biological Science Applications In Agriculture Applications In Medicine

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