Abstract
Several aryl N-hydroxy- and N-methoxy- N-methylcarbamates were examined as inhibitors of bovine erythrocyte acetylcholinesterase (AChE). These carbamate derivatives were generally strong inhibitors of AChE, but, unlike the typical N-methyl- and N,N-dimethylcarbamates which are carbamylating agents, they proved to be reversible, competitive inhibitors of the enzyme. The values for the dissociation constant ( K a ) for the enzyme-inhibitor complex to enzyme and inhibitor were in the range of 2 × 10 −5−1 × 10 −7 M.
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