Abstract
Matrix metalloproteinase 14 (MMP14) is a pericellular collagenase expressed at high levels in adipose tissue. Li et al. (e00564-19) used an adipose tissue-specific and doxycycline-inducible MMP14 overexpression model to study the effects of this factor in obese mice. They found that overexpressing MMP14 in established obese fat leads to unhealthy metabolic effects via the production of endotrophin, a known fibrotic factor that triggers local inflammation. They further revealed that hypoxia-induced hypoxia-inducible factor 1α binds to the MMP14 promoter to upregulate MMP14 expression in obese fat. These findings suggest that MMP14 may be a key player in adipose tissue remodeling during the development of obesity.
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