Abstract
Antimicrobial peptides (AMPs) are promising antibacterials because of their low propensity for resistance development and their ability to kill resistant bacteria. Kathayat et al. (e00567-21) showed that small peptides (NPSRQERR, PDENK, and VHTAPK) were effective in reducing infections with avian pathogenic Escherichia coli (APEC), a form of extraintestinal pathogenic E. coli (ExPEC), in chickens. Further, they showed that these peptides likely affect MlaA-OmpC/F, a system critical for maintaining bacterial outer membrane lipid asymmetry, which represents a high-value target for treating antibiotic-resistant infections. This work highlights a valuable approach for development of novel therapies for ExPEC and other related Gram-negative pathogens.
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