Abstract
Filoviruses utilize a complex entry pathway to initiate infection, which requires extensive proteolytic processing of the viral glycoprotein (GP) in the endosome/lysosome prior to membrane fusion. Lennemann et al. (e01073-21) have identified a single amino acid polymorphism in early isolates of Sudan virus (SUDV) GP at position 95 which has a significant impact on GP-mediated entry due to changes in protein stability. This polymorphism, located in the base of GP, alters the efficacy of inhibitors of GP-mediated entry in a species-specific manner. This work highlights unique characteristics of GPs among filovirus species, which may pose a challenge for the development of pan-filovirus antivirals.
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