Abstract
WD repeat domain 77 protein (WDR77) plays an essential role in cellular proliferation during the early stages of development and is reactivated during tumorigenesis. Altayyar et al. (e00302-20) demonstrate that WDR77 regulates the translation of E2F1 and E2F3 (E2F1/3) mRNAs via their 5’ untranslated regions. WDR77 physically interacts with programmed cell death 4 (PDCD4) to relieve its inhibitory effect on eukaryotic translation initiation factor 4A1. This work reveals for the first time that WDR77 is directly involved in translational regulation of E2F1/3 mRNAs and highlights a mechanism by which WDR77 regulates cellular proliferation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
