Abstract
Fatigue has been ranked as the most perpetual and disruptive of all symptoms in cancer survivors (CS), affecting up to 90% of CS after chemo and radiation therapies. Fatigue also has the greatest impact on quality-of-life in CS. Despite prevalence of fatigue symptom and its impact on CS' everyday life, mechanisms behind cancer-related fatigue (CRF) are not well understood. Based on common observations of lack of motor drive in CRF patients, we hypothesized that central fatigue would play a significant role in limiting CRF patients' ability to sustain motor activities.
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